To evaluate the impact of necrotizing enterocolitis (NEC) on mortality in very low birth weight (VLBW) infants with intraventricular hemorrhage (IVH).
Data were collected on VLBW infants born 2014–2018 at Vermont Oxford Network (VON) centers. NEC and IVH were categorized by severity. Adjusted risk ratios (ARR) for in-hospital mortality were calculated.
This study included 187 187 VLBW infants. Both medical and surgical NEC increased mortality risk compared to those without NEC. Stratification by IVH severity modified this effect (no IVH: ARR 3.04 (95%CI 2.74–3.38) for medical NEC and 4.17 (3.84–4.52) for surgical NEC; mild IVH: ARR 2.14 (1.88–2.44) for medical NEC and 2.49 (2.24–2.78) for surgical NEC; severe IVH: ARR 1.14 (1.03–1.26) for medical NEC and 1.10 (1.02–1.18) for surgical NEC).
The relative impact of NEC on mortality decreased as IVH severity increased. Given the frequent coexistence of NEC and IVH, these data inform multidisciplinary management of these complex patients.
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We thank our colleagues who submit data to VON on behalf of infants and their families. Participating centers are listed in Supplementary Table 1.
Dr. Horbar, Dr. Soll and Ms. Morrow are employees of the Vermont Oxford Network. Dr. Edwards receives salary support from Vermont Oxford Network. The remaining authors do not have financial relationships to disclose.
The authors declare no competing interests.
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
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Culbreath, K., Knell, J., Keefe, G. et al. Impact of concomitant necrotizing enterocolitis on mortality in very low birth weight infants with intraventricular hemorrhage. J Perinatol (2022). https://doi.org/10.1038/s41372-022-01434-1