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Early white matter tract changes in neonates with prenatal opioid exposure: a pilot study

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We would like to thank all the families for their participation in this study and the entire staff at the Tufts Shields MRI for their assistance in organizing and acquiring the images. Authors would also like to acknowledge the following groups for their support: (A) K12 Building Interdisciplinary Research for Careers in Women’s Health; (B) Tufts Tiny Feet Funds.


This study received funding from K12 Building Interdisciplinary Research for Careers in Women’s Health (BIRCWH) Grant #5K12HD092535-05 (EY) and Tufts Tiny Feet Funds (EY). The content is solely the responsibility of the authors and does not necessarily represent the official views of the funding agencies.

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PS critically analyzed the DTI data, performed statistical analysis, interpreted the data, and drafted, reviewed, and finalized the paper. NM designed the study, protocolized, acquired, and read the structural brain MRI images, reviewed the DTI analyses, reviewed and revised the paper. EY conceptualized and designed the study, obtained IRB approval, consented and enrolled patients, performed statistical analysis, interpreted the data, reviewed and revised the paper. All authors approved the final paper as submitted and agree to be accountable for all aspects of the work.

Corresponding author

Correspondence to Elizabeth Yen.

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Competing interests

The authors declare no competing interests.

Ethics approval

The study protocol was approved by the Tufts Institutional Review Board (IRB). Consent from each participant was obtained prior to study enrollment. This study was performed in accordance with the Declaration of Helsinki.

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Sikka, P., Madan, N. & Yen, E. Early white matter tract changes in neonates with prenatal opioid exposure: a pilot study. J Perinatol (2022).

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