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Visual outcomes in children with neonatal hypoxic ischemic encephalopathy treated with therapeutic hypothermia

Journal of Perinatology volume 41, pages 2379–2380 (2021)Cite this article

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Landmark studies have shown that therapeutic hypothermia (TH) decreases the likelihood of death and severe disability in neonatal hypoxic ischemic encephalopathy (HIE) [1]. However, visual outcomes for cooled patients are still largely unexplored [1]. We analyzed longitudinal vision trends in ten patients from 2009 to 2019 with neonatal HIE receiving TH, followed in the division of ophthalmology.

This study was Institutional Review Board approved, and patient information was uploaded to REDCap [2]. Exclusion criteria included patients who did not have neonatal HIE or who did not receive their neonatal care at the institution. HIE severity was determined clinically by the neonatologist as mild, moderate, or severe as described by Sarnat scoring. All patients were cooled for 72 h at 33.5 °C.

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Fig. 1: Visual acuity in subjects on initial visit and over time.

References

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Author notes

  1. These authors contributed equally: Jerry Hsu, Noreen Shaikh

Authors and Affiliations

  1. Department of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

    Jerry Hsu & Rebecca B. Mets-Halgrimson

  2. Division of Ophthalmology, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, USA

    Jerry Hsu, Noreen Shaikh, Hantamalala Ralay Ranaivo & Rebecca B. Mets-Halgrimson

  3. Department of Pediatrics, Ann & Robert H. Lurie Children’s Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

    Andrea C. Pardo

Authors
  1. Jerry Hsu
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  2. Noreen Shaikh
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  3. Hantamalala Ralay Ranaivo
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  4. Andrea C. Pardo
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  5. Rebecca B. Mets-Halgrimson
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Contributions

JH provided substantial contribution to the collection, analysis, and interpretation of data, and was responsible for drafting the manuscript. NS provided substantial contribution to the conception, design, analysis, and interpretation of data, and critically revised the manuscript. HRR provided substantial contribution to the conception, analysis, and interpretation of the data, and critically revised the manuscript. ACP provided substantial contribution to the conception, design, analysis, and interpretation of the data, and critically revised the manuscript. RBM-H provided substantial contribution to the conception, design, analysis, and interpretation of the data, and critically revised the manuscript. All authors gave final approval for the submitted manuscript.

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Correspondence to Rebecca B. Mets-Halgrimson.

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Hsu, J., Shaikh, N., Ranaivo, H.R. et al. Visual outcomes in children with neonatal hypoxic ischemic encephalopathy treated with therapeutic hypothermia. J Perinatol 41, 2379–2380 (2021). https://doi.org/10.1038/s41372-021-01101-x

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  • DOI: https://doi.org/10.1038/s41372-021-01101-x

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