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Correlation of Thompson and modified Sarnat scores in neonatal hypoxic ischemic encephalopathy

Journal of Perinatology volume 41, pages 1522–1523 (2021)Cite this article

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Modified Sarnat staging (SS) [1] and less commonly the Thompson score (TS) [2] have been utilized to assess hypoxic ischemic encephalopathy (HIE) severity and eligibility for therapeutic hypothermia (TH) [3]. We evaluated the correlation between SS and TS, and determined TS values corresponding to the various categories of SS.

For outcomes, 7% died and 29% had abnormal brain MRIs as defined by the Barkovich classification [5]. Among the three time points, the latest score, that at NICU admission, had the best predictive value for death or abnormal MRI for both SS and TS with AUC (95% CI) of 0.715 (0.584, 0.846) and 0.778 (0.633, 0.924) for SS and TS, respectively.

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Fig. 1: Correspondence analysis with biplot of modified Sarnat staging and Thompson score, for all three time points combined.

References

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Acknowledgements

We would like to thank Enza Andreacchi and Michelle Lee for assistance with data entry.

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Authors and Affiliations

  1. Division of Neonatology, The Hospital for Sick Children, Toronto, ON, Canada

    Panadda Chansarn, Ranjit Torgalkar, Diane Wilson, Hilary Whyte & Kyong-Soon Lee

  2. Rogers Computational Program, Ted Rogers Centre for Heart Research, Peter Munk Cardiac Centre, University Health Network, Toronto, ON, Canada

    Chun-Po Steve Fan

  3. Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, ON, Canada

    Elysa Widjaja

  4. Department of Paediatrics, University of Toronto, Toronto, ON, Canada

    Hilary Whyte, Emily W. Y. Tam & Kyong-Soon Lee

  5. Division of Neurology, The Hospital for Sick Children, Toronto, ON, Canada

    Emily W. Y. Tam

Authors
  1. Panadda Chansarn
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  2. Ranjit Torgalkar
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  3. Diane Wilson
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  4. Chun-Po Steve Fan
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  5. Elysa Widjaja
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  6. Hilary Whyte
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  7. Emily W. Y. Tam
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  8. Kyong-Soon Lee
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Contributions

PC contributed to the concept/design; acquisition, analysis and interpretation of data; and drafted and revised the manuscript. RT contributed to the concept/design; acquisition, analysis and interpretation of data; and reviewed the manuscript. DW contributed to the concept/design; acquisition, analysis and interpretation of data; and reviewed the manuscript. CPSF contributed to the concept/design; analysis and interpretation of data; and critically revised the manuscript. EW contributed to the acquisition of MRI data and reviewed the manuscript. HW contributed to the concept/design; interpretation of data; and reviewed the manuscript. EWYT contributed to the concept/design; acquisition, analysis and interpretation of data; and critically revised the manuscript. KSL contributed to the concept/design; acquisition, analysis and interpretation of data; and critically revised the manuscript. All authors have approved the manuscript version submitted and agree to be accountable for all aspects of the work.

Corresponding author

Correspondence to Kyong-Soon Lee.

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Conflict of interest

The authors declare no competing interests.

Ethical approval

The study was approved as a healthcare improvement project by the Quality Committee at the Hospital for Sick Children, Toronto, Canada and a waiver of ethics approval was obtained.

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Chansarn, P., Torgalkar, R., Wilson, D. et al. Correlation of Thompson and modified Sarnat scores in neonatal hypoxic ischemic encephalopathy. J Perinatol 41, 1522–1523 (2021). https://doi.org/10.1038/s41372-021-00987-x

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  • DOI: https://doi.org/10.1038/s41372-021-00987-x

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