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Thyroid-stimulating hormone reference ranges for moderate-to-late preterm infants

Abstract

Background:

Identifying congenital hypothyroidism through newborn screening (NBS) is higher among moderate-to-late preterm (MLPT) infants. Currently, the same thyroid-stimulating hormone (TSH) cutoffs are used for term and preterm infants. TSH reference ranges for MLPT infants are not currently available.

Objective:

To determine TSH reference ranges for MLPT infants.

Methods:

We analyzed 10,987 TSH levels on NBS samples performed on 8499 MLPT infants born between 32 and 36 weeks gestation.

Results:

TSH median, 5th, 25th, 75th, 95th, and 99th percentiles were defined from day 1 until day 14 of life. TSH levels gradually decreased after birth and reached a plateau around day 6.

Conclusion:

Using a state-wide cohort, we constructed TSH reference charts from day 1 until day 14 for MLPT infants. Relationship between age-adjusted TSH percentiles and long-term neurodevelopmental outcomes should be determined in future studies to define optimal TSH cutoffs for MLPT infants.

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Fig. 1: TSH reference chart for moderate-to-late preterm infants.
Fig. 2: Ninety-fifth percentile TSH values in extremely preterm (22–27 weeks), very preterm (28–31 weeks) and moderate-to-late preterm (31–36 weeks) infants.

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Correspondence to Dinushan C. Kaluarachchi.

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Kaluarachchi, D.C., Nicksic, V.M., Allen, D.B. et al. Thyroid-stimulating hormone reference ranges for moderate-to-late preterm infants. J Perinatol 41, 2664–2667 (2021). https://doi.org/10.1038/s41372-020-00895-6

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