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What happens to 35 week infants that receive delivery room continuous positive airway pressure?

Journal of Perinatology volume 41, pages 1575–1582 (2021)Cite this article

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Abstract

Objective

Delivery room (DR) continuous positive airway pressure (CPAP) is increasing. Our study examined the risk for neonatal morbidities after DR CPAP in 35 week neonates.

Study design

A retrospective study of 259 infants born at 35 weeks gestational age between January 1, 2017–December 31, 2018 at a single center.

Results

DR resuscitation was administered in 30.5%, with 19.7% receiving CPAP alone. Eighty percent who received DR CPAP were admitted to the NICU. DR CPAP was associated with the highest NICU admission risk, 9.3 times the risk of those without DR positive pressure, and with respiratory conditions (RDS: OR 4.22 {CI 1.46–11.51}, TTN: OR 3.30 {CI 1.36–7.64}). For the DR CPAP group, non-invasive positive pressure was administered post resuscitation in 90%.

Conclusions

In our institution, 35 week infants frequently received DR CPAP. Of these infants, a majority were admitted to the NICU for respiratory disorders.

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Fig. 1
Fig. 2: Indications for neonatal intensive care unit admission by delivery room resuscitation group.

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Acknowledgements

Elli Gourna Paleoudis, PhD for her assistance in protocol development and IRB submission.

Author information

Authors and Affiliations

  1. Hackensack University Medical Center, Joseph M. Sanzari Children’s Hospital, Hackensack, NJ, USA

    Nicole T. Spillane & Themba Nyirenda

  2. Hackensack Meridian School of Medicine at Seton Hall University, Nutley, NJ, USA

    Nicole T. Spillane & Themba Nyirenda

  3. Fordham University, Bronx, NY, USA

    Franchesca Macalintal

  4. SIBEN, The Iberoamerican Society of Neonatology, Wellington, FL, USA

    Sergio G. Golombek

Authors
  1. Nicole T. Spillane
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  2. Franchesca Macalintal
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  3. Themba Nyirenda
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  4. Sergio G. Golombek
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Contributions

Dr. Nicole Spillane conceptualized and designed the study, analyzed data, performed statistical analyses, and drafted the initial manuscript and reviewed and revised the manuscript. Francesca Macalintal designed data collection instruments, performed data collection, carried out initial analyses, and critically reviewed the manuscript. Dr. Themba Nyirenda provided biostatistical support, assisted in study design, and critically reviewed the manuscript. Dr. Sergio Golombek interpreted data and critically reviewed and revised the manuscript.

Corresponding author

Correspondence to Nicole T. Spillane.

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Conflict of interest

The authors have no conflicts of interest or financial disclosures relevant to this article to disclose. This study was approved by the IRB of Hackensack University Medical Center and a waiver of consent and assent was granted. It was performed in accordance with the Declaration of Helsinki.

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Spillane, N.T., Macalintal, F., Nyirenda, T. et al. What happens to 35 week infants that receive delivery room continuous positive airway pressure?. J Perinatol 41, 1575–1582 (2021). https://doi.org/10.1038/s41372-020-00883-w

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