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Impact of human immunodeficiency virus, malaria, and tuberculosis on adverse pregnancy outcomes in the United States

Journal of Perinatology volume 40, pages 240–247 (2020)Cite this article

Subjects

Abstract

Objective

To compare rates of adverse pregnancy outcomes for HIV, tuberculosis, and malaria-infected patients in the United States with those of uninfected patients.

Study design

A nationally representative sample of 24,149,664 singleton live births were identified using pregnancy hospitalizations that resulted in delivery between 1998–2000 and 2009–2011 in this retrospective cohort study. Maternal and fetal outcomes were evaluated.

Results

There were 7204 HIV cases, 1450 TB cases, and 296 malaria cases over the two time periods, and the average age of infected subjects was 28.3. The HIV group was more likely to have almost all adverse pregnancy outcomes than the control group in both time periods. The 2009–2011 HIV group was more likely to undergo cesarean delivery than the 1998–2000 HIV group [1959 versus 1649, p < 0.0001].

Conclusion

Out of pregnant women infected with HIV, malaria, or tuberculosis, those infected with HIV are more likely to experience several adverse pregnancy outcomes than uninfected women.

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Author information

Authors and Affiliations

  1. GW Medical Faculty Associates, Department of Obstetrics and Gynecology, The George Washington University, Washington, DC, USA

    Homa K. Ahmadzia

  2. Gratitude Circle, LLC, Centreville, VA, USA

    Najma Khorrami

  3. Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

    Najma Khorrami

  4. The George Washington University School of Medicine and Health Sciences, Washington, DC, USA

    Jené A. Carter

  5. University of North Carolina School of Medicine, Chapel Hill, NC, USA

    Juliana Stone

  6. GW Medical Faculty Associates, Department of Surgery, The George Washington University, Washington, DC, USA

    Richard L. Amdur

Authors
  1. Homa K. Ahmadzia
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  4. Juliana Stone
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Correspondence to Homa K. Ahmadzia.

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Ahmadzia, H.K., Khorrami, N., Carter, J.A. et al. Impact of human immunodeficiency virus, malaria, and tuberculosis on adverse pregnancy outcomes in the United States. J Perinatol 40, 240–247 (2020). https://doi.org/10.1038/s41372-019-0512-9

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  • DOI: https://doi.org/10.1038/s41372-019-0512-9

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