To determine the frequency of abnormal findings on evaluation of neonates with congenital CMV infection who have a normal physical examination
Retrospective, 2-center study (1996–2017) that reviewed results of complete blood cell count and platelets, serum alanine aminotransferase (ALT) and bilirubin concentrations, eye examination, cranial ultrasonography or other neuroimaging, and brainstem evoked responses performed on neonates with congenital CMV infection and a normal physical examination
Of 34 infants with congenital CMV infection and a normal physical examination, 56% (19/34) had ≥1 abnormality: 39%, elevated ALT concentration; 45%, abnormal neuroimaging (five, lenticulostriate vasculopathy; six, intraventricular hemorrhage; four, calcifications); 12%, anemia; 16%, thrombocytopenia; and 3%, chorioretinitis. Seven (21%) infants had sensorineural hearing loss, and 18 infants received antiviral therapy.
Some infants with congenital CMV infection and a normal physical examination had abnormalities on laboratory or neuroimaging evaluation, which in some cases prompted antiviral treatment.
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AR received grant support from “A. Griffini—J. Miglierina” Fundation—Provincia di Varese Piazza Libertà 1- 21100 Varese-Italy. The Fundation was not involved in the (1) study design, (2) the collection, analysis, and interpretation of data; (3) the writing of the report; and (4) the decision to submit the paper for publication. AR wrote the first draft of the paper. The other authors have no financial relationships relevant to this article to disclose.
Conflict of interest
The authors declare that they have no conflict of interest.
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The study was presented in part at the 4th Congenital Cytomegalovirus Conference, San Francisco, CA, October 29–31, 2012, and at the Pediatric Academic Societies’ Annual Meeting, Vancouver, BC, May 3–6, 2014
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Ronchi, A., Zeray, F., Lee, L.E. et al. Evaluation of clinically asymptomatic high risk infants with congenital cytomegalovirus infection. J Perinatol (2019) doi:10.1038/s41372-019-0501-z