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Hypertensive disorders during pregnancy are associated with reduced severe intraventricular hemorrhage in very-low-birth-weight infants

Journal of Perinatology volume 39, pages 1125–1130 (2019)Cite this article

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Abstract

Objective

To determine differences in severe intraventricular hemorrhage (IVH) between very-low-birth-weight (≤1500 g, VLBW) infants born to mothers with and without hypertensive disorders (HD).

Design/methods

Retrospective analysis from the Optum Neonatal Database. The primary outcome of interest was severe IVH (grade 3 or 4). Secondary outcomes included other neonatal morbidities, mortality, and length of hospitalization. Outcomes were compared between VLBW infants born to mothers with and without HD.

Results

A total of 5456 infants met inclusion criteria. After multivariable regression analysis, risks of severe IVH and bronchopulmonary dysplasia (BPD) were lower ([OR 0.42, 95% CI 0.33–0.89, p = 0.01] and [OR 0.75, 95% CI 0.58–0.97, p = 0.03], respectively) and median length of hospitalization was decreased in the HD group (49 versus 61 days, p < 0.001).

Conclusions

VLBW infants born to mothers with HD have a decreased risk of severe IVH, BPD, and a shorter duration of hospitalization.

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Authors and Affiliations

  1. Neonatology, Thomas Jefferson University Hospital/Nemours, Philadelphia, PA, USA

    Amy J. Sloane, Margaret Lafferty, Jay Greenspan & Zubair H. Aghai

  2. Neonatology, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA

    Dustin D. Flannery, Erik A. Jensen & Kevin Dysart

  3. Optum, Atlanta, GA, USA

    Alison Cook

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Sloane, A.J., Flannery, D.D., Lafferty, M. et al. Hypertensive disorders during pregnancy are associated with reduced severe intraventricular hemorrhage in very-low-birth-weight infants. J Perinatol 39, 1125–1130 (2019). https://doi.org/10.1038/s41372-019-0413-y

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