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Trends in the incidence, mortality, and cost of neonatal herpes simplex virus hospitalizations in the United States from 2003 to 2014

Journal of Perinatology volume 39, pages 697–707 (2019)Cite this article

Subjects

Abstract

Objective

To examine the temporal trends in the incidence and outcomes of neonatal herpes simplex infections (NHSV) in the United States.

Study design

We conducted a retrospective study using the National Inpatient Sample (NIS). Neonates ≤28 days old with ICD-9 codes for NHSV (054.xx) from 2003 to 2014 were included. Trends in the incidence, mortality, length of stay (LOS), and hospital cost were analyzed using Jonckheere–Terpstra test.

Results

NHSV increased from 7.9 to 10 per 100,000 live births from 2003–05 to 2012–14 (P = 0.04). Hospital costs increased from $21,650 to $27,843; P < 0.001). The overall mortality rate and median LOS were 7.9% and 20 days, respectively and there were no significant variations across years during the study period.

Conclusions

The incidence of NHSV in the United States increased between 2003 and 2014 without a significant change in mortality. NHSV remains a serious health threat and new and effective strategies to prevent NHSV are needed.

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Acknowledgements

The authors acknowledge the Healthcare Cost and Utilization Project (HCUP) sponsored by the Agency for Healthcare Research and Quality, Rockville, MD and its partner organizations that provide data to the HCUP. A list of all HCUP data partners is available at https://www.hcup-us.ahrq.gov/db/hcupdatapartners.jsp.

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Authors and Affiliations

  1. Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL, USA

    Keyur Donda, Mayank Sharma & Fredrick Dapaah-Siakwan

  2. The Trust Hospital, Accra, Ghana

    Jason K. Amponsah

  3. Department of Pediatrics, Texas Tech Health Sciences Center, Amarillo, TX, USA

    Parth Bhatt

  4. Korle Bu Teaching Hospital, Accra, Ghana

    Michael Okaikoi

  5. Department of Pediatrics, University of Connecticut School of Medicine, Farmington, CT, USA

    Riddhi Chaudhari

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Correspondence to Fredrick Dapaah-Siakwan.

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Donda, K., Sharma, M., Amponsah, J.K. et al. Trends in the incidence, mortality, and cost of neonatal herpes simplex virus hospitalizations in the United States from 2003 to 2014. J Perinatol 39, 697–707 (2019). https://doi.org/10.1038/s41372-019-0352-7

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