Outcomes of preterm infants conceived with in vitro fertilization

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Abstract

Objectives

To determine if there is increased risk of prematurity-related complications for in vitro fertilization (IVF)-conceived preterm infants compared to matched controls.

Study Design

Cohort study of 23–34 weeks’ preterm infants from 329 US NICUs discharged from 2009 to 2016. Each IVF patient was matched to three controls.

Results

We identified 6,756 IVF-conceived preterm infants who were matched with 20,268 controls. IVF-conceived infants had no increase in non-respiratory morbidities but had significantly higher rates of bronchopulmonary dysplasia (8.4% vs 7%, p < 0.001) and significantly greater exposure to common chronic respiratory medications.

Conclusions

In this large cohort of IVF-conceived preterm infants we found similar outcomes to controls with the exception of bronchopulmonary dysplasia and respiratory medication exposure. Further research is needed to explore the influence of in vitro fertilization on the development of neonatal respiratory disease.

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Author contribution

KAA conceptualized and designed the study, analyzed and interpreted data, drafted the initial manuscript, and approved the final manuscript as submitted. PR, RHC, and VNT conceptualized and designed the study, analyzed and interpreted data, critically reviewed and revised the manuscript, and approved the final manuscript as written. CAC analyzed and interpreted data, critically reviewed and revised the manuscript, and approved the final manuscript as written. MMB carried out the data analyses, critically reviewed and revised the manuscript, and approved the final manuscript as written.

Author information

Correspondence to Kaashif Aqeeb Ahmad.

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The authors declare that they have no conflict of interest.

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Ahmad, K.A., Bennett, M.M., Rayburn, P. et al. Outcomes of preterm infants conceived with in vitro fertilization. J Perinatol 39, 717–722 (2019) doi:10.1038/s41372-019-0332-y

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