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Histological chorioamnionitis at term according to labor onset: a prospective controlled study

Journal of Perinatology volume 39, pages 581–587 (2019)Cite this article

Subjects

Abstract

Objective

To study the incidence of histological chorioamnionitis (HCA) in term pregnancies according to labor onset.

Study design

During 2013–6, term pregnancy placentas were prospectively sent to histopathology evaluation, and compared between patients with spontaneous onset labor, pre-labor ROM, labor induction and elective cesarean deliveries.

Results

A total of 260 placentas were obtained, 65 from each group. Rates of HCA for the spontaneous labor, PROM, induction and CD groups were: 49, 32, 24 and 4%, respectively (p < 0.001). Composite neonatal outcome was non-significant between the study groups, and between cases with and without HCA. In a logistic regression model, after controlling for parity - gestational age, mode of delivery, ROM > 12 h and spontaneous onset of labor were found to be independent risk factors for HCA.

Conclusion

HCA at term is prevalent in spontaneous labor and supports the association between the inflammatory processes and activation of the physiological signals of parturition.

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Author contribution:

HGH, LS, HM and MBZ were involved in the acquisition of data, design of the manuscript, drafting of the article, final approval of the version to be published and provided agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. JB and MK were involved in the analysis and interpretation of data, conception and design of manuscript, revising it critically for important intellectual content, final approval of the version to be published and provided agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

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Author notes

  1. These authors contributed equally: Hadas Ganer Herman, Letizia Schreiber

Authors and Affiliations

  1. Department of Obstetrics & Gynecology, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, the Edith Wolfson Medical Center, Holon, Israel

    Hadas Ganer Herman, Hadas Miremberg, Masha Ben Zvi, Jacob Bar & Michal Kovo

  2. Department of Pathology, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, the Edith Wolfson Medical Center, Holon, Israel

    Letizia Schreiber

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  1. Hadas Ganer Herman
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Correspondence to Hadas Ganer Herman.

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The abstract of this study was presented as a poster at the 38th annual meeting of the Society of Maternal Fetal Medicine, on January 2018, at Dallas, Texas.

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Ganer Herman, H., Schreiber, L., Miremberg, H. et al. Histological chorioamnionitis at term according to labor onset: a prospective controlled study. J Perinatol 39, 581–587 (2019). https://doi.org/10.1038/s41372-019-0327-8

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