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The use of less invasive surfactant administration (LISA) in the United States with review of the literature

Journal of Perinatologyvolume 39pages426432 (2019) | Download Citation



The majority of extremely low gestational age neonates undergo intubation for surfactant therapy. Less invasive surfactant administration (LISA) uses a thin catheter inserted into the trachea to deliver the surfactant. During the procedure, the infant is breathing spontaneously while supported with continuous positive airway pressure. Although LISA is widely adapted in Europe and Australia, the rate of LISA use in the United States is unknown.

Study design

The aim of this study is to evaluate the use of LISA in the US. A web-based survey was distributed via SurveyMonkey to 2550 neonatologists from AAP’s SoNPM mailing list.


Of the 472 neonatologists who answered the survey, 15% used LISA either as a part of routine care (8%) or as part of research (7%).


Unlike several regions of Europe, LISA is not widely used in the US. Future studies should address ambiguities regarding infant selection, procedure training and “roadblocks” to its broader application.

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Special thanks to Dr. James Cummings for his comments and help with editing this article. We also thank Jithin John, DO student, for the help with data processing.


No funding has been received for this study.

Author information


  1. Cohen Children’s Medical Center, New Hyde Park, NY, USA

    • Dalibor Kurepa
    • , Shahana Perveen
    •  & Yisrael Lipener
  2. University of Texas Southwestern Medical Center, Dallas, TX, USA

    • Venkatakrishna Kakkilaya


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The authors declare that they have no conflict of interest.

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Correspondence to Dalibor Kurepa.

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