Article | Published:

Post-ligation cardiac syndrome is associated with increased morbidity in preterm infants

Journal of Perinatologyvolume 38pages537542 (2018) | Download Citation

Abstract

Objective

The influence of post-ligation cardiac syndrome (PLCS), a complication of patent ductus arteriosus (PDA) ligations, on neonatal outcomes is unknown. The purpose of this study was to determine the risks of PLCS on severe pulmonary morbidity and severe retinopathy of prematurity (ROP).

Study design

Retrospective cohort study of infants who underwent a PDA ligation between 2006 and 2015. Data were collected on patients with and without PLCS. The primary outcome was the difference in severe bronchopulmonary dysplasia (BPD) between groups. Secondary outcomes included discharge with home oxygen and severe ROP.

Result

A total of 100 infants that underwent PDA ligation during the study period were included in the study; 31 (31%) neonates developed PLCS. In adjusted analysis, PLCS was associated with increased risk for severe BPD (RR 1.67, 95% CI: 1.15–2.42) and home oxygen therapy (RR: 1.47, 95% CI: 1.09–1.99) only. No association with severe ROP was seen (RR: 1.48; 95% CI: 0.87–2.52).

Conclusion

PLCS is associated with severe neonatal pulmonary morbidity, but not with severe ROP. Further investigation is warranted to validate these results.

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Author information

Affiliations

  1. Department of pediatrics, Children’s Mercy Hospital, Kansas City, MO, USA

    • Timothy J. B. Ulrich
    • , Taylor P. Hansen
    •  & Steven L. Olsen
  2. Department of Health Services and Outcomes Research, Children’s Mercy Hospital, Kansas City, MO, USA

    • Kimberly J. Reid
  3. Cardiac Center, Nemours Children’s Hospital, Orlando, FL, USA

    • Michael A. Bingler

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Conflict of interest

The authors declare that they have no conflict of interest.

Corresponding author

Correspondence to Timothy J. B. Ulrich.

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DOI

https://doi.org/10.1038/s41372-018-0056-4