Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Comment
  • Published:

Precision therapeutics in the NICU: why are we missing the mark?

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1


  1. Ward RM, Tammara B, Sullivan SE, Stewart DL, Rath N, Meng X, et al. Single-dose, multiple-dose, and population pharmacokinetics of pantoprazole in neonates and preterm infants with a clinical diagnosis of gastroesophageal reflux disease (GERD). Eur J Clin Pharmacol. 2010;66:555–61.

    Article  CAS  Google Scholar 

  2. Allegaert K, van Schaik RH, Vermeersch S, Verbesselt R, Cossey V, Vanhole C, et al. Postmenstrual age and CYP2D6 polymorphisms determine tramadol o-demethylation in critically ill neonates and infants. Pediatr Res. 2008;63:674–9.

    Article  CAS  Google Scholar 

  3. Zhu R, Kiser JJ, Seifart HI, Werely CJ, Mitchell CD, D’Argenio DZ, et al. The pharmacogenetics of NAT2 enzyme maturation in perinatally HIV exposed infants receiving isoniazid. J Clin Pharmacol. 2012;52:511–9.

    Article  CAS  Google Scholar 

  4. Matic M, Simons SH, van Lingen RA, van Rosmalen J, Elens L, de Wildt SN, et al. Rescue morphine in mechanically ventilated newborns associated with combined OPRM1 and COMT genotype. Pharmacogenomics. 2014;15:1287–95.

    Article  CAS  Google Scholar 

  5. Turner MA, Davis JM, McCune S, Bax R, Portman RJ, Hudson LD. The International Neonatal Consortium: collaborating to advance regulatory science for neonates. Pediatr Res. 2016;80:462–4.

    Article  CAS  Google Scholar 

  6. Lewis T, Dinh J, Leeder JS. Genetic determinants of fetal opiate exposure and risk of neonatal abstinence syndrome: knowledge deficits and prospects for future research. Clin Pharmacol Ther. 2015;98:309–20.

    Article  CAS  Google Scholar 

  7. Giudici V, Pogliani L, Cattaneo D, Dilillo D, Zuccotti GV. Serotonin reuptake inhibitors in pregnancy: can genes help us in predicting neonatal adverse outcome? BioMed Res Int. 2014;2014:276918.

    Article  Google Scholar 

  8. Ounissi M, Benkirane A, Dempsey E, Soares R, Jullien V, Pons G, et al. A review of potential pharmacogenetic effects on catecholamine responses. Drug Metab Rev. 2015;47:558–64.

    Article  CAS  Google Scholar 

Download references

Author contributions

TL conceptualized the article, performed necessary lit review, designed the table and figures, and wrote the manuscript.

Author information

Authors and Affiliations


Corresponding author

Correspondence to Tamorah Lewis.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lewis, T. Precision therapeutics in the NICU: why are we missing the mark?. J Perinatol 38, 444–446 (2018).

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links