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Pulse wave velocity during re-feeding and with weight gain in underweight female adolescents with anorexia nervosa


Anorexia Nervosa (AN) causes harmful underweight and important cardiovascular acute complications however less is known about longer-term cardiovascular risk. We measured carotid femoral pulse wave velocity (PWV) in a group of underweight young women with AN at baseline and weekly as they were refed and gained weight. PWV decreased over time and was negatively associated with increasing BMI and calorific meal content suggesting potential positive cardiovascular benefits for refeeding and weight gain in AN and supports current consensus for the importance of weight gain in underweight young women with AN.

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Fig. 1: Graphs of changes in key variables over time and tables of longitudinal models.

Data availability

Additional data are available from the corresponding author on request.


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We would like to acknowledge and thank the young people who took part in the study.


The study was funded by a competitive charitable grant by “Former EMS School” in the United Kingdom.

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Authors and Affiliations



LH conceptualised and designed the study with input from HA-K, AT, AR, DN, RV and AH. Study delivery was managed by LH, MM, HA_K. Data was collected by MM. Analysis was performed by LH and MCB. LH and AH produced the first draft, but all authors contributed expertise and input to the final content of the paper.

Corresponding author

Correspondence to Lee D. Hudson.

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The authors declare no competing interests.

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We received research ethics approval from a London health research ethics committee.

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Hudson, L.D., Al-Khairulla, H., Maicoo, M. et al. Pulse wave velocity during re-feeding and with weight gain in underweight female adolescents with anorexia nervosa. J Hum Hypertens 37, 1126–1128 (2023).

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