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Renal denervation for atrial fibrillation: the issue of bias due to nonblinding

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The data underlying this study are available from the corresponding author.


  1. Nawar K, Mohammad A, Johns EJ, Abdulla MH. Renal denervation for atrial fibrillation: a comprehensive updated systematic review and meta-analysis. J Hum Hypertens. 2022.

  2. Higgins JPT, Altman DG, Gøtzsche PC, Jüni P, Moher D, Oxman AD, et al. The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. BMJ. 2011;343:d5928.

    Article  Google Scholar 

  3. Pranata R, Vania R, Raharjo SB. Efficacy and safety of renal denervation in addition to pulmonary vein isolation for atrial fibrillation and hypertension—systematic review and meta-analysis of randomized controlled trials. J Arrhythmia. 2020;36:386–94.

    Article  Google Scholar 

  4. Sterne JAC, Savović J, Page MJ, Elbers RG, Blencowe NS, Boutron I, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019;366:l4898.

    Article  Google Scholar 

  5. Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al. (eds.). Cochrane Handbook for Systematic Reviews of Interventions. 2nd edn. Hoboken: Wiley Blackwell; 2019.

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No financial support was received for this study.

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All authors contributed to the conception and design of this study, drafting and critical revision of the article, and gave final approval for it.

Corresponding author

Correspondence to Huzaifa Ahmad Cheema.

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Competing interests

The authors declare no competing interests.

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No ethical approval was required for this study as it is a letter to the editor and not based on any human data.


No consent was required for this study.

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Cheema, H.A., Shahid, A. Renal denervation for atrial fibrillation: the issue of bias due to nonblinding. J Hum Hypertens (2022).

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