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Comparison of brachial–ankle pulse wave velocity and carotid–femoral pulse wave velocity in association with albuminuria in a community of Beijing: a cross-sectional study


This study was performed to investigate and compare the association of albuminuria with the brachial–ankle pulse wave velocity (baPWV) and carotid–femoral pulse wave velocity (cfPWV) in a community-based population in Beijing. Subjects were enrolled from a follow-up survey conducted in 2018 from an atherosclerosis cohort in Shijingshan district, Beijing, China. The baPWV and cfPWV were measured using a BP-203 RPE III arteriosclerosis detection device and PulsePen, respectively. Albuminuria was defined as a urinary albumin–creatinine ratio of ≥30 mg/g. A multivariate logistic regression model was used to evaluate the impacts of different PWV measurements on the prevalence of albuminuria. In total, 5605 subjects were included in the analyses. Their mean age was 62.22 ± 7.55 years, and the prevalence of albuminuria was 8.22%. In the multivariate logistic regression model adjusted for potential covariates, both baPWV (odds ratio [OR], 1.06; 95% confidence interval [CI], 1.03–1.10; P < 0.001) and cfPWV (OR, 1.07; 95% CI, 1.01–1.14; P = 0.018) were significantly associated with albuminuria. Furthermore, when baPWV and cfPWV were entered into the logistic regression model simultaneously, only baPWV was significantly associated with albuminuria using either continuous value (OR, 1.05; 95% CI, 1.01–1.10; P = 0.007) or classified into quartiles (highest vs. lowest value group: OR, 1.55; 95% CI, 1.01–2.37; P for trend = 0.019). Both cfPWV and baPWV were positively associated with albuminuria, while baPWV had a stronger relationship than cfPWV. Thus, baPWV measurement could be considered for the purpose of community health screening.

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Fig. 1: The prevalence of albuminuria increased with PWV.

Data availability

The data used to support the findings of this study are available from the corresponding author upon request.


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We are very grateful to the staff of the Gucheng and Pingguoyuan Community Health Centers and the research coordinators who participated in this cohort study. This work was supported by funding from the following: UMHS-PUHSC Joint Institute for Translational and Clinical Research and the Fundamental Research Funds for the Central Universities (BMU20110177, BMU20160530); National Key Research and Development Program of China (2017YFC1307704); Scientific Research Seed Fund of Peking University First Hospital (2018SF003, 2018SF071, 2018SF073); Projects of National Natural Science Foundation of China (81703288); Key Laboratory of Molecular Cardiovascular Sciences(Peking University), Ministry of Education and NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides.

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TW was responsible for conducting the search, screening potentially eligible studies, interpreting results, updating reference lists and writing the paper; FF was responsible for conducting the search, extracting and analyzing data, interpreting results; YG contributed to screening potentially eligible studies; JJ contributed to writing the protocol and report, conducting the search, writing the funding resources; LG, ZL, ML, and YJ contributed to data extraction and provided feedback on the report; YZ and JL was responsible for designing the review protocol, screening potentially eligible studies, interpreting results and revising the manuscript.

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Correspondence to Yan Zhang or Jianping Li.

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The authors declare no competing interests.

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This research protocol was approved by the Biomedical Research Ethics Committee of Peking University First Hospital.

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Wang, T., Fan, F., Gong, Y. et al. Comparison of brachial–ankle pulse wave velocity and carotid–femoral pulse wave velocity in association with albuminuria in a community of Beijing: a cross-sectional study. J Hum Hypertens (2022).

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