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Association between hypertension and nonalcoholic fatty liver disease: a cross-sectional and meta-analysis study

Abstract

The association between hypertension and nonalcoholic fatty liver disease (NAFLD) is not completely understood. This study aimed to investigate the association between hypertension and hepatic ultrasound examination-diagnosed positive NAFLD in healthy people; to conduct a comprehensive meta-analysis combining the results of previous studies; to explore whether hypertension was a risk factor for NAFLD. This study included 2049 adults (male: 870 and female: 1179), aged ≥20 years, whose anthropometric parameters were measured to analyze the risk of hypertension on NAFLD. We also collected data from 11 cross-sectional studies relevant to this topic using PubMed, Embase, Web of Science, CNKI, Wanfang, and CQVIP from beginning till 31 August 2020 and combined it with our data for a meta-analysis to explore whether hypertension was a risk factor for NAFLD. After adjusting for confounding factors, the odds of NAFLD in hypertensive subjects was 1.473 (95%CI: 1.119–1.938). After combining with 10 selected studies, 42711 participants were enrolled in meta-analysis. Hypertension was a risk factor for NAFLD (Z = 13.46, P < 0.001); the odds of NAFLD in hypertensive subjects was 1.43 (95%CI: 1.36–1.51). The results were consistent with the results of the meta-analysis. Further studies are required to confirm these results.

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Fig. 1: Flowchart of studies selection.
Fig. 2: Forest plot and sensitivity analysis for hypertension and NAFLD.

Data availability

All data generated or analyzed during this study are included in this published article and its Supplementary Information Files.

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Funding

This work was supported by the National Natural Science Foundation of China (Grant No. 81660562).

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QH and HY conceived and coordinated the study, collected data, performed data analysis and drafted the manuscript; QH and ZC contributed to selected studies and statistical analysis; XZ, YT, and ZQ reviewed and edited the manuscript; All authors read and approved the final manuscript.

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Correspondence to Zhenyu Quan.

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Huang, Q., Yu, H., Zhong, X. et al. Association between hypertension and nonalcoholic fatty liver disease: a cross-sectional and meta-analysis study. J Hum Hypertens (2022). https://doi.org/10.1038/s41371-022-00686-w

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