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Association between isolated systolic hypertension in young adults and future cardiovascular mortality: three clues prove it

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  1. Williams B, Mancia G, Spiering W, Agabiti Rosei E, Azizi M, Burnier M.ESC Scientific Document Group et al. 2018 ESC/ESH guidelines for the management of arterial hypertension. Eur Heart J. 2018;39:3021–104.

    Article  PubMed  Google Scholar 

  2. Palatini P, Rosei EA, Avolio A, Bilo G, Casiglia E, Ghiadoni L, et al. Isolated systolic hypertension in the young: a position paper endorsed by the European Society of Hypertension. J Hypertens. 2018;36:1222–36.

    CAS  Article  PubMed  Google Scholar 

  3. Franklin SS, Pio JR, Wong ND, Larson MG, Leip EP, Vasan RS, et al. Predictors of new-onset diastolic and systolic hypertension: the Framingham Heart Study. Circulation. 2005;111:1121–7.

    Article  PubMed  Google Scholar 

  4. Sharman JE, Avolio AP, Baulmann J, Benetos A, Blacher J, Blizzard CL, et al. Validation of non-invasive central blood pressure devices: ARTERY Society task force consensus statement on protocol standardization. Eur Heart J. 2017;38:2805–12.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Saladini F, Fania C, Mos L, Mazzer A, Casiglia E, Palatini P. Office Pulse pressure is a predictor of favorable outcome in young- to middle-aged subjects with stage 1 hypertension. Hypertension. 2017;70:537–542.

  6. Yano Y, Stamler J, Garside DB, Daviglus ML, Franklin SS, Carnethon MR, et al. Isolated systolic hypertension in young and middle-aged adults and 31-year risk for cardiovascular mortality: the Chicago Heart Association Detection Project in Industry study. J Am Coll Cardiol. 2015;65:327–35.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Lee H, Yano Y, Cho SMJ, Park JH, Park S, Lloyd-Jones DM, et al. Cardiovascular risk of isolated systolic or diastolic hypertension in young adults. Circulation. 2020;141:1778–86.

    Article  PubMed  Google Scholar 

  8. Seryan A, Martin M, Hamimatunnisa J, Annette P, Margit H, Karl-Heinz L. Cardiovascular mortality risk in young adults with isolated systolic hypertension: findings from population-based MONICA/KORA cohort study. J Hum Hypertens. 2021. Epub ahead of print.

  9. McEniery CM, Yasmin, Wallace S, Maki-Petaja K, McDonnell B, Sharman JE, et al. ENIGMA Study Investigators. Increased stroke volume and aortic stiffness contribute to isolated systolic hypertension in young adults. Hypertension. 2005;46:221–6.

    CAS  Article  PubMed  Google Scholar 

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GP, RC, MDA, and GV conceived the presented idea, contributed to data extraction, discussed the results and equally contributed to the final manuscript.

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Correspondence to Giacomo Pucci.

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Pucci, G., Curcio, R., D’Abbondanza, M. et al. Association between isolated systolic hypertension in young adults and future cardiovascular mortality: three clues prove it. J Hum Hypertens 36, 341–343 (2022).

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