Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Association between isolated systolic hypertension in young adults and future cardiovascular mortality: three clues prove it

This is a preview of subscription content

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. Williams B, Mancia G, Spiering W, Agabiti Rosei E, Azizi M, Burnier M.ESC Scientific Document Group et al. 2018 ESC/ESH guidelines for the management of arterial hypertension. Eur Heart J. 2018;39:3021–104.

    Article  PubMed  Google Scholar 

  2. Palatini P, Rosei EA, Avolio A, Bilo G, Casiglia E, Ghiadoni L, et al. Isolated systolic hypertension in the young: a position paper endorsed by the European Society of Hypertension. J Hypertens. 2018;36:1222–36.

    CAS  Article  PubMed  Google Scholar 

  3. Franklin SS, Pio JR, Wong ND, Larson MG, Leip EP, Vasan RS, et al. Predictors of new-onset diastolic and systolic hypertension: the Framingham Heart Study. Circulation. 2005;111:1121–7.

    Article  PubMed  Google Scholar 

  4. Sharman JE, Avolio AP, Baulmann J, Benetos A, Blacher J, Blizzard CL, et al. Validation of non-invasive central blood pressure devices: ARTERY Society task force consensus statement on protocol standardization. Eur Heart J. 2017;38:2805–12.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Saladini F, Fania C, Mos L, Mazzer A, Casiglia E, Palatini P. Office Pulse pressure is a predictor of favorable outcome in young- to middle-aged subjects with stage 1 hypertension. Hypertension. 2017;70:537–542.

  6. Yano Y, Stamler J, Garside DB, Daviglus ML, Franklin SS, Carnethon MR, et al. Isolated systolic hypertension in young and middle-aged adults and 31-year risk for cardiovascular mortality: the Chicago Heart Association Detection Project in Industry study. J Am Coll Cardiol. 2015;65:327–35.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Lee H, Yano Y, Cho SMJ, Park JH, Park S, Lloyd-Jones DM, et al. Cardiovascular risk of isolated systolic or diastolic hypertension in young adults. Circulation. 2020;141:1778–86.

    Article  PubMed  Google Scholar 

  8. Seryan A, Martin M, Hamimatunnisa J, Annette P, Margit H, Karl-Heinz L. Cardiovascular mortality risk in young adults with isolated systolic hypertension: findings from population-based MONICA/KORA cohort study. J Hum Hypertens. 2021. Epub ahead of print.

  9. McEniery CM, Yasmin, Wallace S, Maki-Petaja K, McDonnell B, Sharman JE, et al. ENIGMA Study Investigators. Increased stroke volume and aortic stiffness contribute to isolated systolic hypertension in young adults. Hypertension. 2005;46:221–6.

    CAS  Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations



GP, RC, MDA, and GV conceived the presented idea, contributed to data extraction, discussed the results and equally contributed to the final manuscript.

Corresponding author

Correspondence to Giacomo Pucci.

Ethics declarations

Competing interests

The authors declare no competing interests.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Pucci, G., Curcio, R., D’Abbondanza, M. et al. Association between isolated systolic hypertension in young adults and future cardiovascular mortality: three clues prove it. J Hum Hypertens 36, 341–343 (2022).

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI:


Quick links