Information on the association between homocysteine (HCY) levels and carotid atherosclerosis (CAS) in hypertension (HTN) is limited. A cross-sectional study was performed to examine the relationship of plasma HCY concentration with CAS in 1700 hypertensives (61.62 ± 12.16 year). The prevalence of CAS and carotid intima–media thickness (CIMT) progressively increased across quartiles of HCY levels (P < 0.001). Correlation analysis showed significantly positive correlation between HCY and CAS (r = 0.261, P < 0.001). In a logistic regression, HCY independently predicted the presence of CAS (OR 1.284, 95% CI 1.163–1.418). Further investigation revealed that interaction effect of HCY was substantial for gender (P for interaction 0.023), age (P for interaction <0.001) and smoking (P for interaction 0.025) on CAS. Thus, in hypertensives, those of male, aged ≥55 year and current smokers, in which HCY ≥ 13.49 μmol/L were more likely to suffer CAS, suggesting a role of HCY in the development and progression of CAS in these patients, and HCY determination should be recommended to better stratify the cardiovascular risk.
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The authors thank the participants and participating physicians from The First Affiliated Hospital of Fujian Medical University, China.
This work was supported by National Natural Science Foundation of China [Grant Number: 82170355].
The authors declare no competing interests.
Ethics approval and consent to participate
Our study was in accordance with the ethical standards formulated in the Helsinki Declaration, and the protocol was approved by Branch for Medical Research and Clinical Technology Application, Ethics Committee of the First Affiliated Hospital of Fujian Medical University (IEC-FOM-013-2.0). Informed consent was obtained from all patients involved.
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Chen, A., Wu, W., Gong, J. et al. Association of homocysteine with carotid atherosclerosis in hypertension. J Hum Hypertens (2022). https://doi.org/10.1038/s41371-022-00665-1