Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

High normal blood pressure value, is the patient at increased CV risk?

This is a preview of subscription content

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. Williams B, Mancia G, Spiering W, Agabiti Rosei E, Azizi M, Burnier M, et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension: The Task Force for the management of arterial h. J Hypertens. 2018;36:1953–2041.

    CAS  Article  Google Scholar 

  2. Al-Makki A, DiPette D, Whelton PK, Murad MH, Mustafa RA, Acharya S, et al. Hypertension pharmacological treatment in adults: a World Health Organization Guideline executive summary. Hypertension. 2021:HYPERTENSIONAHA12118192.

  3. Whelton PK, Carey RM, Aronow WS, Casey DE Jr., Collins KJ, Dennison Himmelfarb C, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Pr. Hypertension. 2018;71:e13–e115.

    CAS  PubMed  Google Scholar 

  4. de Simone G, Mancusi C, Esposito R, De Luca N, Galderisi M. Echocardiography in arterial hypertension. High Blood Press Cardiovasc Prev. 2018;25:159–66.

    Article  Google Scholar 

  5. Maloberti A, Rebora P, Occhino G, Alloni M, Musca F, Belli O, et al. Prevalence of hypertension mediated organ damage in subjects with high-normal blood pressure without known hypertension as well as cardiovascular and kidney disease. J Hum Hypertens. 2021. Online ahead of print.

  6. Devereux RB, Wachtell K, Gerdts E, Boman K, Nieminen MS, Papademetriou V, et al. Prognostic significance of left ventricular mass change during treatment of hypertension. JAMA 2004;292:2350–6.

    CAS  Article  Google Scholar 

  7. Izzo R, Losi MA, Stabile E, Lönnebakken MT, Canciello G, Esposito G, et al. Development of left ventricular hypertrophy in treated hypertensive outpatients: the Campania Salute Network. Hypertension. 2017;69:136–42.

    CAS  Article  Google Scholar 

  8. Lønnebakken MT, Izzo R, Mancusi C, Gerdts E, Losi MA, Canciello G, et al. Left ventricular hypertrophy regression during antihypertensive treatment in an outpatient clinic (the Campania Salute Network). J Am Heart Assoc. 2017;6:e004152.

  9. Mancusi C, Gerdts E, Losi MA, D’Amato A, Manzi MV, Canciello G, et al. Differential effect of obesity on prevalence of cardiac and carotid target organ damage in hypertension (the Campania Salute Network). Int J Cardiol. 2017;244:260–4.

    Article  Google Scholar 

  10. Chen X, Barywani SB, Hansson PO, Rosengren A, Thunström E, Zhong Y, et al. High-normal blood pressure conferred higher risk of cardiovascular disease in a random population sample of 50-year-old men: a 21-year follow-up. Medicines. 2020;99:e19895.

    Google Scholar 

  11. Lydia A, Setiati S, Soejono CH, Istanti R, Marsigit J, Azwar MK. Prevalence of prehypertension and its risk factors in midlife and late life: Indonesian family life survey 2014-2015. BMC Public Health. 2021;21:493.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations



CM drafted the manuscript, IF and CB review the manuscript and gave final approval.

Corresponding author

Correspondence to Costantino Mancusi.

Ethics declarations

Competing interests

The authors declare no competing interests.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Mancusi, C., Basile, C. & Fucile, I. High normal blood pressure value, is the patient at increased CV risk?. J Hum Hypertens (2022).

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • DOI:


Quick links