Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Malignant hypertension and atypical hemolytic uremic syndrome: a possible continuum between two entities?

This is a preview of subscription content

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: H&E staining, 20×.


  1. Cremer A, Amraoui F, Lip GYH, Morales E, Rubin S, Segura J, et al. From malignant hypertension to hypertension-MOD: a modern definition for an old but still dangerous emergency. J Hum Hypertens. 2016;30:463–6.

    CAS  Article  Google Scholar 

  2. Karpman D, Loos S, Tati R, Arvidsson I. Haemolytic uraemic syndrome. J Intern Med. 2017;281:123–48.

    Article  Google Scholar 

  3. Bayer G, Von Tokarski F, Thoreau B, Bauvois A, Barbet C, Cloarec S, et al. Etiology and outcomes of thrombotic microangiopathies. Clin J Am Soc Nephrol. 2019;14:557–66.

    Article  Google Scholar 

  4. Timmermans SAMEG, Werion A, Damoiseaux JGMC, Morelle J, Reutelingsperger CP, van Paassen P. Diagnostic and risk factors for complement defects in hypertensive emergency and thrombotic microangiopathy. Hypertension. 2020;75:422–30.

  5. Palma LMP, Sridharan M, Sethi S. Complement in secondary thrombotic microangiopathy. Kidney Int Rep. 2021;6:11–23. [Internet] Available from:

    Article  PubMed  Google Scholar 

  6. Timmermans SAMEG, Abdul-Hamid MA, Potjewijd J, Theunissen ROMFIH, Damoiseaux JGMC, Reutelingsperger CP, et al. C5b9 formation on endothelial cells reflects complement defects among patients with renal thrombotic microangiopathy and severe hypertension. J Am Soc Nephrol. 2018;29:2234–43.

    CAS  Article  Google Scholar 

  7. Timmermans SAMEG, Abdul-Hamid MA, Vanderlocht J, Damoiseaux JGMC, Reutelingsperger CP, van Paassen P, et al. Patients with hypertension-associated thrombotic microangiopathy may present with complement abnormalities. Kidney Int. 2017;91:1420–5. [Internet] Available from:

    Article  PubMed  Google Scholar 

  8. Cavero T, Arjona E, Soto K, Caravaca-Fontán F, Rabasco C, Bravo L, et al. Severe and malignant hypertension are common in primary atypical hemolytic uremic syndrome. Kidney Int. 2019;96:995–1004.

    CAS  Article  Google Scholar 

  9. Demeulenaere M, Devreese K, Vanbelleghem H, De Zaeytijd J, Vande Walle J, Van Biesen W, et al. Thrombomodulin and endothelial dysfunction: a disease-modifier shared between malignant hypertension and atypical hemolytic uremic syndrome. Nephron. 2018;140:63–73.

    CAS  Article  Google Scholar 

  10. Gavriilaki E, Brodsky RA. Complementopathies and precision medicine. J Clin Invest. 2020;130:2152–63.

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations



ACB and BGR concept and drafted the article; ACB, ASS, and AL revised the paper; MVC, PSC, and BGR made the critical revision of the article; all authors approved the final version of the paper.

Corresponding author

Correspondence to Ana Catarina Brás.

Ethics declarations

Competing interests

The authors declare no competing interests.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Brás, A.C., Santos, A.S., Lima, A. et al. Malignant hypertension and atypical hemolytic uremic syndrome: a possible continuum between two entities?. J Hum Hypertens 36, 498–499 (2022).

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI:


Quick links