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Is it time to reconsider the treatment paradigm for obese patients with hypertension?

The recent STEP trials reported blood pressure reductions for obese patients treated with semaglutide. We analyzed a cohort of patients attending our hypertension clinic and found that 26% were severely or morbidly obese and morbidly obese patients frequently had resistant hypertension (41%). We suggest semaglutide may be an effective anti-hypertensive agent for obese patients with resistant hypertension and this hypothesis should be assessed in randomized clinical trials.

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Authors and Affiliations



CK was responsible for study concept and design, data acquisition, interpretation and analysis, drafting of the paper and final approval. RF was responsible for study concept and design, data acquisition and analysis, drafting of the paper and final approval. JS was responsible for study concept and design, data acquisition and interpretation, critical revision of the paper and final approval. POC, M Hall, M Hennessy and MB were responsible for study supervision, data acquisition and interpretation, critical review of the paper and final approval.

Corresponding author

Correspondence to Cormac Kennedy.

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Competing interests

The authors report no relationships that could be construed as a competing interests. JS is a clinical specialist at the clinic while also working in pharmaceutical industry. His employer does not manufacture anti-hypertensive medications.

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Ethical approval was granted by the Tallaght Hospital Research Ethics Committee.

Informed consent

Informed consent was sought and provided by all study participants.

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Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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Kennedy, C., Ali, O., Farnan, R. et al. Is it time to reconsider the treatment paradigm for obese patients with hypertension?. J Hum Hypertens 36, 482–484 (2022).

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