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Epidemiology and control of hypertension in Japan: a comparison with Western countries

Abstract

Based on data from national surveys, the prevalence of hypertension rests at 40–60% in Japan, the USA, and in European countries. This suggests there has been little progress in the prevention of hypertension in even high-income countries despite their well-functioning health systems. In particular, compared with the USA and European countries, the improvement in awareness, treatment, and control of hypertension has been relatively low in Japan. For example, the rates of hypertension awareness, treatment, and control were observed, respectively, in 60–70%, 50–60%, and 20–30% of Japanese compared with 80–90%, 70–80%, and 50–60% of US citizens in the years around 2015. The lower proportions in Japan might be explained by the slower progress in lowering the accepted thresholds for diagnosis of hypertension and initiation of treatment compared with Western countries; however, the underlying reasons for the differences warrant further study. The high prevalence (>40%) of uncontrolled hypertension in even high-income countries has major implications for the prevention of cardiovascular disease. Health policy and research on early control of high blood pressure at the individual and public health levels will contribute to decreases in the prevalence of hypertension. Furthermore, proactive treatment and strict adherence to intensified antihypertensive treatment guidelines will more effectively achieve targeted blood pressure levels. In this context, it is important to continue to carefully monitor and compare trends in hypertension across countries.

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Fig. 1: Trends in mean systolic blood pressure across age groups by sex from 1961 to 2016 in Japan.
Fig. 2: Trends in mean diastolic blood pressure across age groups by sex from 1961 to 2016 in Japan.
Fig. 3: Trends in the prevalence of hypertension across age groups by sex from 1980 to 2016 in Japan. Hypertension was defined as blood pressure ≥140/90 mmHg or the use of antihypertensive medication.
Fig. 4: Trends in the treatment rate of hypertension across age groups by sex from 1980 to 2016 in Japan. The treatment rate was calculated as the proportion of use of antihypertensive medication among patients with hypertension.
Fig. 5: Trends in the control rate of hypertension across age groups by sex from 1980 to 2016 in Japan. The control rate of hypertension was defined as the proportion of those with BP < 140/90 mmHg among hypertensive patients taking antihypertensive medication.
Fig. 6: Prevalence of hypertension and rates of awareness, treatment, and control in women aged 40–79 years in 12 high-income countries.
Fig. 7: Prevalence of hypertension and rates of awareness, treatment, and control in men aged 40–79 years in 12 high-income countries.

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References

  1. GBD 2017 Risk Facotr Collaborators. Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018;392:1923–94.

    Article  Google Scholar 

  2. Bundy JD, Li C, Stuchlik P, Bu X, Kelly TN, Mills KT, et al. Systolic blood pressure reduction and risk of cardiovascular disease and mortality: a systematic review and network meta-analysis. JAMA Cardiol. 2017;2:775–81.

    Article  Google Scholar 

  3. NCD Risk Factor Collaboration Long-term and recent trends in hypertension awareness, treatment, and control in 12 high-income countries: an analysis of 123 nationally representative surveys. Lancet. 2019;394:639–51.

    Article  Google Scholar 

  4. Ikeda N, Sapienza D, Guerrero R, Aekplakorn W, Naghavi M, Mokdad AH, et al. Control of hypertension with medication: a comparative analysis of national surveys in 20 countries. Bull World Health Organ. 2014;92:10–19C.

    Article  Google Scholar 

  5. Miura K Report for a Health and Labor Sciences Research Grant, Japan (Comprehensive research on life-style related diseases including cardiovascular diseases and diabetes mellitus [H30-Jyunkankitou-Seisyu-Sitei-002]); 2019 (in Japanese).

  6. Hisamatsu T, Segawa H, Kadota A, Ohkubo T, Arima H, Miura K. Epidemiology of hypertension in Japan: beyond the new 2019 Japanese guidelines. Hypertens Res. 2020;43:1344–51.

    Article  CAS  Google Scholar 

  7. Nagai M, Ohkubo T, Murakami Y, Takashima N, Kadota A, Miyagawa N, et al. Secular trends of the impact of overweight and obesity on hypertension in Japan, 1980-2010. Hypertens Res. 2015;38:790–5.

    Article  Google Scholar 

  8. Umemura S, Arima H, Arima S, Asayama K, Dohi Y, Hirooka Y, et al. The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019). Hypertens Res. 2019;42:1235–481.

    Article  Google Scholar 

  9. Whelton PK, Carey RM, Aronow WS, Casey DE Jr, Collins KJ, Dennison Himmelfarb C, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology/American Heart Association task force on clinical practice guidelines. Hypertension. 2018;71:e13–e115.

    CAS  Google Scholar 

  10. Williams B, Mancia G, Spiering W, Agabiti Rosei E, Azizi M, Burnier M, et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension: the task force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension: the task force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension. J Hypertens. 2018;36:1953–2041.

    Article  CAS  Google Scholar 

  11. Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. Global burden of hypertension: analysis of worldwide data. Lancet. 2005;365:217–23.

    Article  Google Scholar 

  12. Mills KT, Bundy JD, Kelly TN, Reed JE, Kearney PM, Reynolds K, et al. Global disparities of hypertension prevalence and control: a systematic analysis of population-based studies from 90 countries. Circulation. 2016;134:441–50.

    Article  Google Scholar 

  13. Hisamatsu T, Liu K, Chan C, Krefman AE, Fujiyoshi A, Budoff MJ, et al. Coronary artery calcium progression among the US and Japanese men. Circ Cardiovasc Imaging. 2019;12:e008104.

    Article  Google Scholar 

  14. Intersalt Cooperative Research Group. Intersalt: an international study of electrolyte excretion and blood pressure. Results for 24h urinary sodium and potassium excretion. BMJ. 1988;297:319–28.

    Article  Google Scholar 

  15. Taddei S, Bruno R, Masi S, Solini A Epidemiology and pathophysiology of hypertension. In: Camm J, Lüscher TF, Maurer G, Serruys PW, editors. ESC CardioMed (3rd edition), Oxford: Oxford University Press; 2018. https://oxfordmedicine.com/view/10.1093/med/9780198784906.001.0001/med-9780198784906-chapter-563 (Access 1 Nov 2020).

  16. Dickinson BD, Havas S. Council on science and public health, American Medical Association. Reducing the population burden of cardiovascular disease by reducing sodium intake: a report of the Council on Science and Public Health. Arch Intern Med. 2007;167:1460–8.

    Article  CAS  Google Scholar 

  17. Smith SR, Klotman PE, Svetkey LP. Potassium chloride lowers blood pressure and causes natriuresis in older patients with hypertension. J Am Soc Nephrol. 1992;2:1302–9.

    CAS  PubMed  Google Scholar 

  18. Zhou BF, Stamler J, Dennis B, Moag-Stahlberg A, Okuda N, Robertson C, et al. Nutrient intakes of middle-aged men and women in China, Japan, United Kingdom, and United States in the late 1990s: the INTERMAP study. J Hum Hypertens. 2003;17:623–30.

    Article  CAS  Google Scholar 

  19. Powles J, Fahimi S, Micha R, Khatibzadeh S, Shi P, Ezzati M, et al. Global, regional and national sodium intakes in 1990 and 2010: a systematic analysis of 24 h urinary sodium excretion and dietary surveys worldwide. BMJ Open. 2013;3:e003733.

    Article  Google Scholar 

  20. Otani T, Iwasaki M, Yamamoto S, Sobue T, Hanaoka T, Inoue M, et al. Alcohol consumption, smoking, and subsequent risk of colorectal cancer in middle-aged and elderly Japanese men and women: Japan Public Health Center-based prospective study. Cancer Epidemiol Biomark Prev. 2003;12:1492–500.

    CAS  Google Scholar 

  21. Ueshima H, Sekikawa A, Miura K, Turin TC, Takashima N, Kita Y, et al. Cardiovascular disease and risk factors in Asia: a selected review. Circulation. 2008;118:2702–9.

    Article  Google Scholar 

  22. Virdis A, Giannarelli C, Neves MF, Taddei S, Ghiadoni L. Cigarette smoking and hypertension. Curr Pharm Des. 2010;16:2518–25.

    Article  CAS  Google Scholar 

  23. GBD 2015 Obesity Collaborators, Afshin A, Forouzanfar MH, Reitsma MB, Sur P, Estep K, et al. Health effects of overweight and obesity in 195 countries over 25 years. N Engl J Med. 2017;377:13–27.

    Article  Google Scholar 

  24. Guthold R, Stevens GA, Riley LM, Bull FC. Worldwide trends in insufficient physical activity from 2001 to 2016: a pooled analysis of 358 population-based surveys with 1.9 million participants. Lancet Glob Health. 2018;6:e1077–e1086.

    Article  Google Scholar 

  25. Sekikawa A, Hayakawa T. Prevalence of hypertension, its awareness and control in adult population in Japan. J Hum Hypertens. 2004;18:911–2.

    Article  CAS  Google Scholar 

  26. Japanese Society of Hypertension Guidelines Subcommittee for the Management of Hypertension. Guidelines for the management of hypertension for general practitioners. Hypertens Res. 2001;24:613–34.

    Article  Google Scholar 

  27. The fifth report of the Joint National Committee on Detection. Evaluation, and treatment of high blood pressure (JNC V). Arch Intern Med. 1993;153:154–83.

    Article  Google Scholar 

  28. Ikeda N, Hasegawa T, Hasegawa T, Saito I, Saruta T. Awareness of the Japanese Society of Hypertension guidelines for the management of hypertension (JSH 2000) and compliance to its recommendations: surveys in 2000 and 2004. J Hum Hypertens. 2006;20:263–6.

    Article  CAS  Google Scholar 

  29. Hyman DJ, Pavlik VN. Self-reported hypertension treatment practices among primary care physicians: blood pressure thresholds, drug choices, and the role of guidelines and evidence-based medicine. Arch Intern Med. 2000;160:2281–6.

    Article  CAS  Google Scholar 

  30. Node K, Kishi T, Tanaka A, Itoh H, Rakugi H, Ohya Y, et al. The Japanese Society of Hypertension-Digest of plan for the future. Hypertens Res. 2018;41:989–90.

    Article  Google Scholar 

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Acknowledgements

We thank Eleanor Scharf, MSc(A), from Edanz Group (https://en-author-services.edanzgroup.com/ac) for editing a draft of this manuscript.

Funding

The NIPPON DATA80/90/2010 were supported by Grants-in-Aid from the Ministry of Health, Labour and Welfare under the auspices of the Japanese Association for Cerebro-cardiovascular Disease Control; a Research Grant for Cardiovascular Diseases (7A-2) from the Ministry of Health, Labour and Welfare; and a Health and Labour Sciences Research Grant, Japan (Comprehensive Research on Aging and Health [H11-Chouju-046, H14-Chouju-003, H17-Chouju-012, H19-Chouju-Ippan-014] and Comprehensive Research on Life-Style Related Diseases including Cardiovascular Diseases and Diabetes Mellitus [H22-Junkankitou-Seishuu-Sitei-017, H25- Junkankitou-Seishuu-Sitei-022, H30-Junkankitou-Seishuu-Sitei-002]).

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Correspondence to Takashi Hisamatsu.

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Hisamatsu, T., Miura, K. Epidemiology and control of hypertension in Japan: a comparison with Western countries. J Hum Hypertens (2021). https://doi.org/10.1038/s41371-021-00534-3

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