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A greater burden of atrial fibrillation is associated with worse endothelial dysfunction in hypertension

Journal of Human Hypertension volume 35, pages 667–677 (2021)Cite this article

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Abstract

Atrial fibrillation (AF) and hypertension often co-exist and both are associated with endothelial dysfunction. We hypothesised that AF would further worsen endothelium-dependent flow-mediated dilatation (FMD) in hypertension patients compared to those without AF. In a cross-sectional comparison, we measured brachial artery diameter at rest and during reactive hyperaemia following 5 min of arterial occlusion in two patient groups: AF (and hypertension) (n = 61) and hypertension control groups (n = 33). The AF (and hypertension) subgroups: permanent AF (n = 30) and paroxysmal AF (n = 31) were also assessed. The permanent AF patients received heart rate and blood pressure (BP) control optimisation and were then followed up after eight weeks for repeat FMD testing. There was no significant difference in FMD between AF (and hypertension) group and hypertension control group (4.6%, 95% CI [2.6–5.9%] vs 2.6%, 95% CI [1.9–5.3%]; p = 0.25). There was a significant difference in FMD between permanent AF and paroxysmal AF groups (3.1%, 95% CI [2.3–4.8%] vs 5.9%, 95% CI [4.0–8.1%]; p = 0.02). Endothelium-dependent FMD response showed a non-significant improvement trend following eight weeks of heart rate and BP optimisation (3.1%, 95% CI [2.3–4.8%] (baseline) vs 5.2%, 95% CI [3.9–6.5%] (follow up), p = 0.09). Presence of AF generally does not incrementally worsen endothelial dysfunction in hypertension patients, although the duration and frequency of AF (paroxysmal AF to permanent AF) does lead to worsening endothelial function. Eight weeks of BP optimisation did not significantly improve endothelial dysfunction as measured by FMD.

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Fig. 1: Medication use by class of drugs.
Fig. 2: Complex interplay between hypertension.

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Acknowledgements

The time and effort expended by all the participants is greatly appreciated.

Author contributions

GYHL has served as a consultant for Bayer/Janssen, BMS/Pfizer, Biotronik, Medtronic, Boehringer Ingelheim, Microlife and Daiichi-Sankyo; and a speaker for Bayer, BMS/Pfizer, Medtronic, Boehringer Ingelheim, Microlife, Roche and Daiichi-Sankyo. No personal fees received.

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Author notes

  1. These authors contributed equally: G. Neil Thomas, James P. Fisher, Gregory Y.H. Lip

Authors and Affiliations

  1. Institute of Applied Health Research, University of Birmingham, Birmingham, United Kingdom

    Ahsan A. Khan & G. Neil Thomas

  2. School of Sport, Exercise and Rehabilitation Sciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, United Kingdom

    Rehan T. Junejo

  3. Liverpool Centre for Cardiovascular Science, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, United Kingdom

    Rehan T. Junejo & Gregory Y. H. Lip

  4. Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, United Kingdom

    Reem Alsharari

  5. Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand

    James P. Fisher

  6. Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Faculty of Health, Aalborg University, Aalborg, Denmark

    Gregory Y. H. Lip

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Correspondence to Gregory Y. H. Lip.

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Khan, A.A., Junejo, R.T., Alsharari, R. et al. A greater burden of atrial fibrillation is associated with worse endothelial dysfunction in hypertension. J Hum Hypertens 35, 667–677 (2021). https://doi.org/10.1038/s41371-020-0383-8

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