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The association between sleep duration and hypertension: a meta and study sequential analysis


Hypertension is a global public issue, and sleep duration was regarded as its risk factors, however, the results were inconsistent. This study aims to deeply investigate and assess the association between sleep duration and hypertension. The electronic databases Cochrane Library, Pubmed and Embase updated to April, 30, 2020 were retrieved. Cohort studies that compared the long or short sleep duration versus normal sleep duration for the incidence of hypertension were included. The associations between sleep duration and hypertension were analyzed by meta-analyses, using risk ratio and 95% confidence interval as effect indexes. TSA software was used to assess the reliability of the pooled results and estimate the required sample size. A total of 11 studies (involving 85,838 subjects) were eligible for this meta-analysis. The association between short sleep duration and hypertension had statistical significances (RR = 1.161, 95% CI: 1.058–1.274), while there was no significant difference in ≥8 h group (RR = 1.059, 95% CI: 0.951–1.180). For short sleep hours, the required information size was calculated to be 44,889, and the number of subjects included in the meta-analysis exceeded the required information size. For long sleep hours, the required information size was 92,368, and the number of included subjects was less than that. The short sleep duration was confirmed to be a risk factor of the incidence of hypertension, future research should be conducted for some in-depth exploration. However, the significant association between long sleep duration and hypertension was not found, more studies should be conducted to confirm the pooled results.

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Fig. 1
Fig. 2: Short sleep duration and hypertension.
Fig. 3: Long sleep duration and hypertension.

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We gratefully acknowledge all research assistants for their contribution to this study. This study was funded by Social Science foundation of Ministry of Education of China (grant number: 18XJC910001).

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Correspondence to Ziqian Zeng.

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Wang, L., Hu, Y., Wang, X. et al. The association between sleep duration and hypertension: a meta and study sequential analysis. J Hum Hypertens 35, 621–626 (2021).

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