Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Does 24-h ambulatory blood pressure monitoring act as ischemic preconditioning and influence endothelial function?

Journal of Human Hypertension volume 33, pages 817–820 (2019)Cite this article

Subjects

Abstract

Ischemic preconditioning can exert a powerful protection against a subsequent period of ischemia, via repeated inflation and deflation of a blood pressure cuff. Most often, damages of ischemia-reperfusion injury and benefits of preconditioning are evaluated via endothelial function. The ambulatory blood pressure monitoring constitutes repeated bouts of ischemia for 24 h. We examined whether repeated bouts of ischemia accumulated over 24 h influenced endothelial function. Twenty-two apparently healthy non-medicated middle-aged subjects 41 (8) years participated in the study. This study was registered with ClinicalTrials.gov (NCT03303404). Flow-mediated dilation (FMD) was measured as an index of endothelium-dependent vasodilation. The ambulatory blood pressure monitoring device went through an average of 110 (13) inflation/deflation cycles, which resulted in 46 (6) min of cumulative ischemic stimuli. Following 24-h of ambulatory blood pressure monitoring, FMD did not change significantly 6.6 (2.0) vs. 6.8 (2.7)%. Similarly, shear rate and reactive hyperemia were unchanged. We concluded that ambulatory blood pressure monitoring did not influence endothelium-dependent vasodilation acting via ischemic preconditioning.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Get just this article for as long as you need it

$39.95

Learn more

Prices may be subject to local taxes which are calculated during checkout

Fig. 1

References

  1. Thijssen DH, Maxwell J, Green DJ, Cable NT, Jones H. Repeated ischaemic preconditioning: a novel therapeutic intervention and potential underlying mechanisms. Exp Physiol. 2016;101:677–92.

    Article  CAS  Google Scholar 

  2. Galetta F, Franzoni F, Plantinga Y, Ghiadoni L, Rossi M, Prattichizzo F, et al. Ambulatory blood pressure monitoring and endothelium-dependent vasodilation in the elderly athletes. Biomed Pharmacother. 2006;60:443–7.

    Article  CAS  Google Scholar 

  3. Whittaker P, Przyklenk K. From ischemic conditioning to ‘hyperconditioning’: clinical phenomenon and basic science opportunity. Dose Response. 2014;12:650–63.

    Article  Google Scholar 

  4. Tomai F, Crea F, Gaspardone A, Versaci F, De Paulis R, Polisca P, et al. Effects of A1 adenosine receptor blockade by bamiphylline on ischaemic preconditioning during coronary angioplasty. Eur Heart J. 1996;17:846–53.

    Article  CAS  Google Scholar 

  5. Hodges GJ, Stewart DG, Davison PJ, Cheung SS. Episodic bouts of hyperaemia and shear stress improve arterial blood flow and endothelial function. Eur J Appl Physiol. 2018;118:795–803.

    Article  Google Scholar 

  6. DeVan AE, Umpierre D, Harrison ML, Lin H-F, Tarumi T, Renzi CP, et al. Endothelial ischemia-reperfusion injury in humans: association with age and habitual exercise. Am J Physiol-Heart Circ Physiol. 2011;300:H813–H9.

    Article  CAS  Google Scholar 

  7. Tomiyama H, Kohro T, Higashi Y, Takase B, Suzuki T, Ishizu T, et al. Reliability of measurement of endothelial function across multiple institutions and establishment of reference values in Japanese. Atherosclerosis. 2015;242:433–42.

    Article  CAS  Google Scholar 

  8. Harris RA, Nishiyama SK, Wray DW, Richardson RS. Ultrasound assessment of flow-mediated dilation. Hypertension 2010;55:1075–85.

    Article  CAS  Google Scholar 

  9. Pickering TG, Shimbo D, Haas D. Ambulatory blood-pressure monitoring. New Engl J Med. 2006;354:2368–74.

    Article  CAS  Google Scholar 

  10. Machin DR, Park W, Alkatan M, Mouton M, Tanaka H. Hypotensive effects of solitary addition of conventional nonfat dairy products to the routine diet: a randomized controlled trial. Am J Clin Nutr. 2014;100:80–7.

    Article  CAS  Google Scholar 

  11. Jones H, Nyakayiru J, Bailey TG, Green DJ, Cable NT, Sprung VS, et al. Impact of eight weeks of repeated ischaemic preconditioning on brachial artery and cutaneous microcirculatory function in healthy males. Eur J Prev Cardiol. 2015;22:1083–7.

    Article  Google Scholar 

Download references

Acknowledgements

The authors would like to thank the volunteers that donated their time to guarantee the accomplishment of this study.

Author information

Authors and Affiliations

  1. Cardiovascular Aging Research Laboratory, Department of Kinesiology and Health Education, The University of Texas at Austin, Austin, TX, 78712, USA

    Brandon G. Fico, Weili Zhu & Hirofumi Tanaka

Authors
  1. Brandon G. Fico
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Weili Zhu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hirofumi Tanaka
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hirofumi Tanaka.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Additional information

Publisher’s note: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Fico, B.G., Zhu, W. & Tanaka, H. Does 24-h ambulatory blood pressure monitoring act as ischemic preconditioning and influence endothelial function?. J Hum Hypertens 33, 817–820 (2019). https://doi.org/10.1038/s41371-019-0214-y

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41371-019-0214-y

Search

Advanced search

Quick links