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Association between central haemodynamics and risk of all-cause mortality and cardiovascular disease: a systematic review and meta-analysis

Journal of Human Hypertension volume 33, pages 531–541 (2019)Cite this article

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Abstract

The aim of this meta-analysis of longitudinal studies was to obtain a valid and cogent assessment of predictive value of central haemodynamic variables for cardiovascular outcomes and all-cause mortality. We searched for eligible articles using MEDLINE, CINAHL, EMBASE and Web of Science between 1 January 1969 and 31 December 2017. We finally included 24 prospective cohort studies, comprising 146,986 individuals for this analysis. Adjusted pooled hazard ratio of total cardiovascular events was 1.10 (95% confidence interval [CI] 1.04–1.16) for a 10 mmHg increase of central systolic pressure, 1.12 (95% CI 1.05–1.19) for a 10 mmHg increase of central pulse pressure and 1.18 (95% CI 1.09–1.27) for a 10% increase of central augmentation index. Furthermore, pooled hazard ratio of all-cause mortality was 1.22 (95% CI 1.14–1.31) for a 10 mmHg increase of central pulse pressure and 1.19 (95% CI 1.05–1.34) for a 10% increase of central augmentation index. Central haemodynamic variables are independent predictors of cardiovascular disease and all-cause mortality. This finding supports the notion that central pressure components and indices could be suitably implemented in clinical practice.

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Acknowledgements

This work was supported by the Natural Science Foundation of Guangdong Province (No. 2015A030313660), the Science and Technology Program of Guangzhou (No.201604020143, No.201604020018, No.201510010254, No.201803040012), the Medical Science and Technology Research Fund of Guangdong Province (No.B2018023), the National Key Research and Development Program of China (No.2017FYC1307603, No.2016YFC1301305), the Science Technology Program of Guangdong Province (No.2014B020212008) and National Natural Science Foundation of China (No. 81300230).

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  1. The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China

    Wen-feng Li & Ying-qing Feng

  2. Department of Cardiology, Guangdong Cardiovascular Institute, Hypertension Research Laboratory, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China

    Yu-qing Huang & Ying-qing Feng

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Li, Wf., Huang, Yq. & Feng, Yq. Association between central haemodynamics and risk of all-cause mortality and cardiovascular disease: a systematic review and meta-analysis. J Hum Hypertens 33, 531–541 (2019). https://doi.org/10.1038/s41371-019-0187-x

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