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Right ventricular remodelling in mild hypertensive patients: role of left ventricular morpho-functional parameters

Journal of Human Hypertension volume 34, pages 293–300 (2020)Cite this article

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Abstract

Previous studies suggested that hypertensive patients with left ventricular (LV) hypertrophy display right ventricular (RV) remodelling. Few data are available about RV remodelling in naive hypertensives without severe cardiac organ damage. Our aim was to evaluate the relationship between RV and LV morpho-functional parameters in never-treated patients with grade 1 hypertension and whether central blood pressure (CBP), inflammatory and metabolic parameters are potentially associated with RV remodelling. 150 never-treated subjects without evidence of diabetes or other cardiovascular diseases were enrolled in our study. We recruited 100 patients with mild hypertension (twenty-four hours blood pressure (24 h BP) ≥ 130/80 mmHg) and 50 normotensive subjects matched for gender, age and body mass index. To estimate the LV/RV parameters, we performed echography as well as arterial tonometry to assess pulse wave analysis/velocity (PWA/PWV). We found 24 h BP, CBP and PWV were higher in hypertensive patients than in normotensives. In addition, LV mass index was higher in hypertensives, and greater RV free wall thickness was observed (5.3 ± 1.4 vs 4.6 ± 1.2 mm, P = 0.02). RV thickness correlated with interventricular septum (IVS), systolic CBP and RV E′ (r = 0.50, P = 0.0001, r = 0.30, P = 0.003, r = −0.24, P = 0.015); linear regression analysis showed a correlation with only IVS (β = 0.39, P = 0.001). RV E′ was correlated with IVS, LV E′ and systolic CBP (r = −0.35, P = 0.0001, r = 0.25, P = 0.012, r = −0.24, P = 0.019); the correlation with IVS and LV E′ (β = −0.310, P = 0.001; β = 0.27, P = 0.004) was confirmed by linear regression analysis. Our study shows RV remodelling is mostly correlated with IVS thickness, supporting the ventricular interdependence hypothesis.

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Authors and Affiliations

  1. Department of Medicine and Surgery, University of Insubria, Varese, Italy

    Andrea Maria Maresca, Christian Mongiardi, Rossana Corso, Laura Robustelli Test, Alessandra Lippi, Lorenzo Montalbetti, Leonardo Campiotti, Sara Moretti, Nicolò Tandurella, Marco Agostinis, Anna Maria Grandi & Luigina Guasti

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  1. Andrea Maria Maresca
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Correspondence to Andrea Maria Maresca.

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Maresca, A.M., Mongiardi, C., Corso, R. et al. Right ventricular remodelling in mild hypertensive patients: role of left ventricular morpho-functional parameters. J Hum Hypertens 34, 293–300 (2020). https://doi.org/10.1038/s41371-019-0185-z

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