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The effects of melatonin supplementation on blood pressure in patients with metabolic disorders: a systematic review and meta-analysis of randomized controlled trials

A Correction to this article was published on 23 October 2019

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The current systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to evaluate the potential effect of melatonin supplementation on blood pressure in patients with metabolic disorders. The following databases were searched until June 2018: PubMed, MEDLINE, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials. Two reviewers independently assessed the eligibility of retrieved studies, extracted data from included trials, and evaluated the risk of bias of included studies. Statistical heterogeneity was tested using Cochran’s Q test and I-square (I2) statistic. Data were pooled using random-effect models and standardized mean difference (SMD) was considered as the effect size. Eight RCTs, out of 743 potential citations, were eligible to be included in the current meta-analysis. The pooled findings indicated a significant reduction in systolic (SBP) (SMD = −0.42; 95% CI, −0.59, −0.25; P < 0.001; I2: 0.0) and diastolic blood pressure (DBP) (SMD = −0.50; 95% CI, −0.72, −0.27; P < 0.001; I2: 37.1) following melatonin supplementation in individuals with metabolic disorders. In summary, the current meta-analysis demonstrated that melatonin supplementation significantly decreased SBP and DBP in patients with metabolic disorders. Additional prospective studies are recommended using higher supplementation doses and longer intervention periods to confirm our findings.

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  • 23 October 2019

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.


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The research grant was provided by Research Deputy of Shiraz University of Medical Sciences (SUMS).

Author contributions

ZA, MA, VO, NM, K-BL, RT and ZK contributed in conception, design, statistical analysis, and drafting of the manuscript. RJR reviewed the manuscript and offered critical comments.

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Correspondence to Zatollah Asemi.

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Akbari, M., Ostadmohammadi, V., Mirhosseini, N. et al. The effects of melatonin supplementation on blood pressure in patients with metabolic disorders: a systematic review and meta-analysis of randomized controlled trials. J Hum Hypertens 33, 202–209 (2019).

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