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Estimating the effect of a reduction of sodium intake in childhood on cardiovascular diseases later in life

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  1. Global Burden of Disease Causes of Death Collaborators. Global, regional, and national age-sex specific mortality for 264 causes of death, 1980-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017;390:1151–210.

    Article  Google Scholar 

  2. Global Burden of Disease Risk Factors Collaborators. Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017;390:1345–422.

    Article  Google Scholar 

  3. Aburto NJ, Ziolkovska A, Hooper L, Elliott P, Cappuccio FP, Meerpohl JJ. Effect of lower sodium intake on health: systematic review and meta-analyses. Br Med J. 2013;346:f1326.

    Article  Google Scholar 

  4. World Health Organization. Global action plan for the prevention and control of noncommunicable diseases 2013-2020. Geneva: World Health Organization. 2013. Accessed 29 September 2016.

  5. Powles J, Fahimi S, Micha R, Khatibzadeh S, Shi P, Ezzati M, et al. Global, regional and national sodium intakes in 1990 and 2010: a systematic analysis of 24h urinary sodium excretion and dietary surveys worldwide. Br Med J Open. 2013;3:e003733.

    Google Scholar 

  6. World Health Organization. Guideline: sodium intake for adults and children. Geneva: World Health Organization (WHO). 2012. Accessed 10 June 2017.

  7. Chen X, Wang Y. Tracking of blood pressure from childhood to adulthood: a systematic review and meta-regression analysis. Circulation. 2008;117:3171–80.

    Article  Google Scholar 

  8. Olsen MH, Angell SY, Asma S, Boutouyrie P, Burger D, Chirinos JA, et al. A call to action and a lifecourse strategy to address the global burden of raised blood pressure on current and future generations: the Lancet Commission on hypertension. Lancet. 2016;388:2665–712.

    Article  Google Scholar 

  9. Geleijnse JM, Hofman A, Witteman JC, Hazebroek AA, Valkenburg HA, Grobbee DE. Long-term effects of neonatal sodium restriction on blood pressure. Hypertension. 1997;29:913–7.

    Article  CAS  Google Scholar 

  10. Krupp D, Shi L, Egert S, Wudy SA, Remer T. Prospective relevance of fruit and vegetable consumption and salt intake during adolescence for blood pressure in young adulthood. Eur J Nutr. 2015;54:1269–79.

    Article  CAS  Google Scholar 

  11. Leyvraz M, Chatelan A, da Costa BR, Taffe P, Paradis G, Bovet P, et al. Sodium intake and blood pressure in children and adolescents: a systematic review and meta-analysis of experimental and observational studies. Int J Epidemiol. 2018(dyy121):1–15.

  12. Theodore RF, Broadbent J, Nagin D, Ambler A, Hogan S, Ramrakha S, et al. Childhood to early-midlife systolic blood pressure trajectories: early-life predictors, effect modifiers, and adult cardiovascular outcomes. Hypertension. 2015;66:1108–15.

    Article  CAS  Google Scholar 

  13. Ettehad D, Emdin CA, Kiran A, Anderson SG, Callender T, Emberson J, et al. Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis. Lancet. 2016;387:957–67.

    Article  Google Scholar 

  14. Hutcheon JA, Chiolero A, Hanley JA. Random measurement error and regression dilution bias. Br Med J. 2010;340:c2289.

    Article  Google Scholar 

  15. Jackson SL, Cogswell ME, Zhao L, Terry AL, Wang CY, Wright J, et al. Association between urinary sodium and potassium excretion and blood pressure among adults in the United States: National Health and Nutrition Examination Survey, 2014. Circulation. 2018;137:237–46.

    Article  CAS  Google Scholar 

  16. Mente A, O’Donnell MJ, Rangarajan S, McQueen MJ, Poirier P, Wielgosz A, et al. Association of urinary sodium and potassium excretion with blood pressure. N Engl J Med. 2014;371:601–11.

    Article  Google Scholar 

  17. DiNicolantonio JJ, O’Keefe JH. Salt and hypertension: what do we know? Curr Opin Cardiol. 2018;33:377–81.

    Article  Google Scholar 

  18. Cook NR, Cohen J, Hebert PR, Taylor JO, Hennekens CH. Implications of small reductions in diastolic blood pressure for primary prevention. Arch Intern Med. 1995;155:701–9.

    Article  CAS  Google Scholar 

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Correspondence to Magali Rios-Leyvraz.

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Rios-Leyvraz, M., Bovet, P. & Chiolero, A. Estimating the effect of a reduction of sodium intake in childhood on cardiovascular diseases later in life. J Hum Hypertens 34, 335–337 (2020).

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