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Comment on the potential role of microRNAs in hypertension

Journal of Human Hypertension volume 32, pages 639–640 (2018)Cite this article

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MicroRNAs (miRNAs) are small non-coding RNAs considered to be of great biological importance and control molecular signaling pathways in various types of hypertension [1]. In general, like classical genes, miRNAs originate from the nucleus and transported to the cytoplasm where they are processed and regulate messenger RNA (mRNA) of target genes by targeting the 3′-untranslated region (3′-UTR) to suppress gene expression [2]. miRNAs which are present in serum have the potential to serve as prognostic and diagnostic biomarkers. Interestingly, circulatory miRNAs can be used as non-invasive biomarkers for many diseases including cardiovascular diseases, cancer, diabetes, and strokes [3,4,5].

Hypertension is a chronic medical condition that is common among populations worldwide [6]. The occurrence of hypertension is increasing in developing countries and it is one of the most important causes of death in older persons. Hypertension results from a complex interaction of genetic and environmental factors [7]. In general, miRNAs control a wide range of cellular mechanisms such as stem cell maintenance, host–viral interaction, apoptosis, cell proliferation, and gene expression. Most importantly, they act as important gene expression regulators, and modulate cardiovascular development and disease progressions. They are emerging as potential biomarkers and therapeutic targets in hypertension and other related diseases [2].

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References

  1. Krishnan R, Mani P, Sivakumar P, Gopinath V, Sekar D. Expression and methylation of circulating microRNA-510 in essential hypertension. Hypertens Res. 2017;40:361–3.

    Article  CAS  Google Scholar 

  2. Sekar D, Shilpa BR, Das AJ. Relevance of microRNA 21 in different types of hypertension. Curr Hypertens Rep. 2017;19:57.

    Article  Google Scholar 

  3. Zhou J, Zhang J. Identification of miRNA-21 and miRNA-24 in plasma as potential early stage markers of acute cerebral infarction. Mol Med Rep. 2014;10:971–6.

    Article  CAS  Google Scholar 

  4. Sekar D, Venugopal B, Sekar P, Ramalingam K. Role of microRNA 21 in diabetes and associated/related diseases. Gene. 2016;582:14–8.

    Article  CAS  Google Scholar 

  5. Kacperska MJ, Walenczak J, Tomasik B. Plasmatic microRNA as potential biomarkers of multiple sclerosis: literature review. Adv Clin Exp Med. 2016;25:775–9.

    Article  Google Scholar 

  6. Wei LK, Au A, Teh LK, Lye HS. Recent advances in the genetics of hypertension. Adv Exp Med Biol. 2017;956:561–81.

    Article  Google Scholar 

  7. Sarkar T, Singh NP. Epidemiology and genetics of hypertension. J Assoc Physicians India. 2015;63:61–98.

    PubMed  Google Scholar 

  8. Kontaraki JE, Marketou ME, Zacharis EA, Parthenakis FI, Vardas PE. MicroRNA-9 and microRNA-126 expression levels in patients with essential hypertension: potential markers of target-organ damage. J Am Soc Hypertens. 2014;8:368–75.

    Article  CAS  Google Scholar 

  9. Torres-Paz YE, Huesca-Gómez C, Sánchez-Muñoz F, Martínez-Alvarado R, Soto Ma E, Torres-Tamayo M et al. Increased expression of miR-33a in monocytes from Mexican hypertensive patients in elevated carotid intima-media thickness. J Hum Hypertens. 2018.

  10. Parikh VN, Jin RC, Rabello S, Gulbahce N, White K, Hale A, et al. MicroRNA-21 integrates pathogenic signaling to control pulmonary hypertension: results of a network bioinformatics approach. Circulation. 2012;125:1520–32.

    Article  CAS  Google Scholar 

  11. Li H, Zhang X, Wang F, Zhou L, Yin Z, Fan J, et al. MicroRNA-21 lowers blood pressure in spontaneous hypertensive rats by upregulating mitochondrial translation. Circulation. 2016;134:734–51.

    Article  CAS  Google Scholar 

  12. Green DE, Murphy TC, Kang BY, Searles CD, Hart CM. PPAR gamma ligands attenuates hypoxia-induced proliferation in human pulmonary artery smooth muscle cells through modulation of microRNA-21. PLoS ONE. 2015;10:e0133391.

    Article  Google Scholar 

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  1. Department of Life Science, Centre for PG Studies and Research,Kristu Jayanti College (Autonomous), Bangalore University, Bangalore, 560064, India

    Durairaj Sekar

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Correspondence to Durairaj Sekar.

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Sekar, D. Comment on the potential role of microRNAs in hypertension. J Hum Hypertens 32, 639–640 (2018). https://doi.org/10.1038/s41371-018-0104-8

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