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Association of SLRPs with carotid artery atherosclerosis in essential hypertensive patients

Journal of Human Hypertension volume 32, pages 564–571 (2018)Cite this article

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Abstract

Recent research suggested that certain small leucine-rich repeat proteoglycans (SLRPs) were involved in the development of atherosclerosis. The present study investigated the relationship between carotid atherosclerosis plaque and the circulating levels of some SLRPs, including decorin, lumican, and osteoglycin, in essential hypertension. In total, 176 essential hypertensive patients were recruited (mean age 62.1 ± 9.4, male 56.8%) in this study and were classified into two groups: patients with carotid artery plaque (n = 105, 60%) and patients without carotid artery plaque (n = 71, 40%). Patients with carotid artery plaque had higher serum concentration of lumican than patients without carotid plaque (58.0 ± 1.6 vs. 52.3 ± 2.1 ng/ml, p = 0.04) after adjusting for conventional cardiovascular risk factors. There were no differences in decorin and osteoglycin between the two groups. Multivariable logistic regression analysis revealed that lumican levels (Odds ratio (OR) per standard deviation increase, 1.598; 95% confidence interval (CI), 1.012 ~ 2.523; p = 0.04), 24-h mean systolic blood pressure (OR, 1.045; 95% CI, 1.012 ~ 1.079; p = 0.006) and the use of angiotensin receptor blocker (OR, 2.813; 95% CI, 1.023 ~ 7.734; p = 0.045) were independently associated with carotid artery plaque. Besides carotid artery plaque, lumican was related to impaired glucose tolerance (r = 0.162, p = 0.046) and adversely related to osteoglycin (r = − 0.273, p < 0.001), whereas unrelated to age, sex, BMI, diabetes, blood pressure, serum lipids, high-sensitivity C-reactive protein, or carotid intima-media thickness in univariate correlation analyses. Circulating lumican was independently associated with carotid atherosclerosis plaque in essential hypertensive patients, indicating that SLRPs might be used as a promising molecular marker for atherosclerosis.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (81400179), General Program of Shanghai Municipal Health and Family Planning Commission (201440530), Science and Technology Fund Project of Shanghai Jiao Tong University School of Medicine (14XJ10070). We gratefully acknowledge the support of Shanghai Jiao Tong University K.C. Wong Medical Fellowship fund.

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Authors and Affiliations

  1. Shanghai Key Laboratory of Vascular Biology, State Key Laboratory of Medical Genomics, Shanghai, China

    Yan Yang, Qi-hong Wu, Yan Li & Ping-jin Gao

  2. Department of Hypertension, Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

    Yan Yang, Qi-hong Wu, Yan Li & Ping-jin Gao

  3. Laboratory of Vascular Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

    Ping-jin Gao

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Correspondence to Ping-jin Gao.

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Yang, Y., Wu, Qh., Li, Y. et al. Association of SLRPs with carotid artery atherosclerosis in essential hypertensive patients. J Hum Hypertens 32, 564–571 (2018). https://doi.org/10.1038/s41371-018-0077-7

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