Abstract
Background
In most societies, women and men systematically differ in consumption of cosmetics and household products, which are interlinked with gendered norms and occupational segregation. We investigated the differences in personal care product (PCP) use and exposure to endocrine disrupting chemicals (EDCs) based on occupation and gender.
Methods
We utilized data from the first to third Korean National Environmental Health Survey analyzing 9218 participants aged 20–59 years engaged in their current occupation for ≥3 months. Frequent PCP use (≥once/week) and exposure to EDCs were analyzed by gender and occupation. We used least-square geometric means (LSGMs) of urinary concentrations of the five EDCs adjusted for covariates.
Results
Manual occupation was most common in men and no paid occupation was most frequent in women. In general, clerical, service, and sales workers showed the highest prevalence of frequent use of hair and body products. Women used body and makeup products more frequently than men. For all five EDCs, similarly, women showed higher urinary levels in all occupation groups. When stratified by gender, the differences in urinary concentration of EDCs across occupation groups were not observed in men. Among women, clerical, service, and sales workers showed higher bisphenol A (BPA) and mono-n-butyl phthalate (MnBP) levels than manual workers.
Conclusions
Differentials in exposure to EDCs by occupation groups were not evident for men. Given the higher urinary concentration of EDCs in women compared to men, interventions to reduce the exposure to EDCs would need to focus on women, especially in clerical, service, and sales occupations.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 6 print issues and online access
$259.00 per year
only $43.17 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Data availability
The data analyzed in this study are from Korean National Environmental Health Survey, which is open for any researchers upon request at National Institute of Environmental Research of Korea (https://www.nier.go.kr/NIER/kor/index.do).
Change history
17 August 2022
A Correction to this paper has been published: https://doi.org/10.1038/s41370-022-00463-4
References
Mullerova D, Kopecky J. White adipose tissue: storage and effector site for environmental pollutants. Physiol Res. 2007;56:375–81.
La Merrill MA, Vandenberg LN, Smith MT, Goodson W, Browne P, Patisaul HB, et al. Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification. Nat Rev Endocrinol. 2020;16:45–57. https://doi.org/10.1038/s41574-019-0273-8.
Suzuki T, Hidaka T, Kumagai Y, Yamamoto M. Environmental pollutants and the immune response. Nat Immunol. 2020;21:1486–95. https://doi.org/10.1038/s41590-020-0802-6.
Aleya L, Uddin MS. Environmental pollutants and the risk of neurological disorders. Environ Sci Pollut Res. 2020;27:44657–8. https://doi.org/10.1007/s11356-020-11272-3.
Johansson HKL, Svingen T, Fowler PA, Vinggaard AM, Boberg J. Environmental influences on ovarian dysgenesis - developmental windows sensitive to chemical exposures. Nat Rev Endocrinol. 2017;13:400–14. https://doi.org/10.1038/nrendo.2017.36.
Farrugia F, Aquilina A, Vassallo J, Pace NP. Bisphenol A and Type 2 Diabetes Mellitus: a review of epidemiologic, functional, and early life factors. Int J Environ Res Public Health. 2021;18:716. https://doi.org/10.3390/ijerph18020716.
Skakkebaek NE. A brief review of the link between environment and male reproductive health: lessons from studies of testicular germ cell cancer. Horm Res Paediatr. 2016;86:240–6. https://doi.org/10.1159/000443400.
Dellinger K, Williams CL. Makeup at work: negotiating appearance rules in the workplace. Gend Soc. 1997;11:151–77.
Short SE, Yang YC, Jenkins TM. Sex, gender, genetics, and health. Am J Public Health. 2013;103:S93–S101. https://doi.org/10.2105/AJPH.2013.301229.
Scarselli A, Corfiati M, Di Marzio D, Marinaccio A, Iavicoli S. Gender differences in occupational exposure to carcinogens among Italian workers. BMC Public Health. 2018;18:413 https://doi.org/10.1186/s12889-018-5332-x.
Butter ME. Are women more vulnerable to environmental pollution? J Hum Ecol. 2017;20:221–6. https://doi.org/10.1080/09709274.2006.11905931.
Lopez-Rodriguez D, Franssen D, Bakker J, Lomniczi A, Parent A-S. Cellular and molecular features of EDC exposure: consequences for the GnRH network. Nat Rev Endocrinol. 2021;17:83–96. https://doi.org/10.1038/s41574-020-00436-3.
Palanza P, Paterlini S, Brambilla MM, Ramundo G, Caviola G, Gioiosa L, et al. Sex-biased impact of endocrine disrupting chemicals on behavioral development and vulnerability to disease: Of mice and children. Neurosci Biobehav Rev. 2021;121:29–46. https://doi.org/10.1016/j.neubiorev.2020.11.015.
Lee M-J, Fried SK. Sex-dependent depot differences in adipose tissue development and function; role of sex steroids. JOMES. 2017;26:172–80. https://doi.org/10.7570/jomes.2017.26.3.172.
Pollack AZ, Mumford SL, Krall JR, Carmichael AE, Sjaarda LA, Perkins NJ, et al. Exposure to bisphenol A, chlorophenols, benzophenones, and parabens in relation to reproductive hormones in healthy women: a chemical mixture approach. Environ Int. 2018;120:137–44. https://doi.org/10.1016/j.envint.2018.07.028.
Taxvig C, Vinggaard AM, Hass U, Axelstad M, Boberg J, Hansen PR, et al. Do parabens have the ability to interfere with steroidogenesis? Toxicological Sci. 2008;106:206–13. https://doi.org/10.1093/toxsci/kfn148.
Park C, Yu SD. Status and Prospects of the Korean National Environmental Health Survey (KoNEHS). J Environ Health Sci. 2014;40:1–9.
Lim S. The associations between personal care products use and urinary concentrations of phthalates, parabens, and triclosan in various age groups: The Korean National Environmental Health Survey Cycle 3 2015–2017. Sci Total Environ. 2020;742:140640.
Kim S, Baek Y-W. Korean National Environmental Health Survey (KoNEHS): The past, present and future of Human Bio-monitoring in Korea. 2nd International Conference on Human Biomonitoring; Berlin, Germany 2016.
Braun JM, Just AC, Williams PL, Smith KW, Calafat AM, Hauser R. Personal care product use and urinary phthalate metabolite and paraben concentrations during pregnancy among women from a fertility clinic. J Exposure Sci Environ Epidemiol. 2014;24:459–66. https://doi.org/10.1038/jes.2013.69.
Final Amended Report on the Safety Assessment of Methylparaben, Ethylparaben, Propylparaben, Isopropylparaben, Butylparaben, Isobutylparaben, and Benzylparaben as used in Cosmetic Products. Int J Toxicol. 2008;27:1–82. https://doi.org/10.1177/109158180802704s01.
Harley KG, Kogut K, Madrigal DS, Cardenas M, Vera IA, Meza-Alfaro G, et al. Reducing phthalate, paraben, and phenol exposure from personal care products in adolescent girls: findings from the HERMOSA intervention study. Environ Health Perspect. 2016;124:1600–7. https://doi.org/10.1289/ehp.1510514.
Park M, Kim S, Kim Y, Nam DJ, Ryoo JH, Lim S. Relationship between personal care products usage and triclosan exposure: the second Korean National Environmental Health Survey (KoNEHS 2012-2014). Ann Occup Environ Med. 2019;31:2. https://doi.org/10.1186/s40557-019-0283-y.
Liu L, Wang Z, Zhao S, Duan J, Tao H, Wang W, et al. Determination of total phthalate in cosmetics using a simple three-phase sample preparation method. Anal Bioanal Chem. 2018;410:1323–31. https://doi.org/10.1007/s00216-017-0774-z.
Koo HJ, Lee BM. Estimated exposure to phthalates in cosmetics and risk assessment. J Toxicol Environ Health, Part A. 2004;67:1901–14. https://doi.org/10.1080/15287390490513300.
Kato K, Silva MJ, Reidy JA, Hurtz D, Malek NA, Needham LL, et al. Mono(2-ethyl-5-hydroxyhexyl) phthalate and mono-(2-ethyl-5-oxohexyl) phthalate as biomarkers for human exposure assessment to di-(2-ethylhexyl) phthalate. Environ Health Perspect. 2004;112:327–30. https://doi.org/10.1289/ehp.6663.
Dirtu AC, Geens T, Dirinck E, Malarvannan G, Neels H, Van Gaal L, et al. Phthalate metabolites in obese individuals undergoing weight loss: urinary levels and estimation of the phthalates daily intake. Environ Int. 2013;59:344–53. https://doi.org/10.1016/j.envint.2013.06.023.
Enke U, Schleussner E, Pälmke C, Seyfarth L, Koch HM. Phthalate exposure in pregnant women and newborns - the urinary metabolite excretion pattern differs distinctly. Int J Hyg Environ Health. 2013;216:735–42. https://doi.org/10.1016/j.ijheh.2013.01.006.
Kim SH, On JW, Pyo H, Ko KS, Won JC, Yang J, et al. Percentage fractions of urinary di(2-ethylhexyl) phthalate metabolites: Association with obesity and insulin resistance in Korean girls. PloS ONE. 2018;13:e0208081 https://doi.org/10.1371/journal.pone.0208081.
Ferguson KK, Colacino JA, Lewis RC, Meeker JD. Personal care product use among adults in NHANES: associations between urinary phthalate metabolites and phenols and use of mouthwash and sunscreen. J Exposure Sci Environ Epidemiol. 2017;27:326–32. https://doi.org/10.1038/jes.2016.27.
Liao C, Kannan K. A Survey of alkylphenols, bisphenols, and triclosan in personal care products from China and the United States. Arch Environ Contamination Toxicol. 2014;67:50–9. https://doi.org/10.1007/s00244-014-0016-8.
SCCS. Opinion on triclosan (antimicrobial resistance). Brussels, Belgium: European Union, 2010 Contract No.: SCCP/1251/09.
Lu S, Yu Y, Ren L, Zhang X, Liu G, Yu Y. Estimation of intake and uptake of bisphenols and triclosan from personal care products by dermal contact. Sci Total Environ. 2018;621:1389–96. https://doi.org/10.1016/j.scitotenv.2017.10.088.
Waikar SS, Sabbisetti VS, Bonventre JV. Normalization of urinary biomarkers to creatinine during changes in glomerular filtration rate. Kidney Int. 2010;78:486–94. https://doi.org/10.1038/ki.2010.165.
EPA. The Bisphenol A section of America’s Children and the Environment, Third Edition. United States Environmental Protection Agency, 2017.
Korea S Classification of Occupations: Statistics Korea; 2018 [cited 2021 July 29]. Available from: http://kssc.kostat.go.kr/ksscNew_web/ekssc/common/selectIntroduce.do?part=2&top_menu=101&bbsId=isco_s&categoryNameCode=030&categoryMenu=001.
Choi W, Kim S, Baek Y-W, Choi K, Lee K, Kim S, et al. Exposure to environmental chemicals among Korean adults-updates from the second Korean National Environmental Health Survey (2012–2014). Int J Hyg Environ Health. 2017;220:29–35. https://doi.org/10.1016/j.ijheh.2016.10.002.
Lim S. The associations between personal care products use and urinary concentrations of phthalates, parabens, and triclosan in various age groups: The Korean National Environmental Health Survey Cycle 3 2015-2017. Sci Total Environ. 2020;742:140640 https://doi.org/10.1016/j.scitotenv.2020.140640.
Park C, Hwang M, Baek Y, Jung S, Lee Y, Paek D, et al. Urinary phthalate metabolite and bisphenol A levels in the Korean adult population in association with sociodemographic and behavioral characteristics: Korean National Environmental Health Survey (KoNEHS) 2012–2014. Int J Hyg Environ Health. 2019;222:903–10. https://doi.org/10.1016/j.ijheh.2019.02.003.
Polinski KJ, Dabelea D, Hamman RF, Adgate JL, Calafat AM, Ye X, et al. Distribution and predictors of urinary concentrations of phthalate metabolites and phenols among pregnant women in the Healthy Start Study. Environ Res. 2018;162:308–17. https://doi.org/10.1016/j.envres.2018.01.025.
Sorrentino E, Vona R, Monterosso D, Giammarioli AM. Gender issues on occupational safety and health. Ann dell’Istituto Super di sanita. 2016;52:190–7.
Butter ME. Are women more vulnerable to environmental pollution? J Hum Ecol. 2006;20:221–6.
Müllerová D, Kopecký J. White adipose tissue: storage and effector site for environmental pollutants. Physiol Res. 2007;56:375–382. https://doi.org/10.33549/physiolres.931022.
Kandaraki E, Chatzigeorgiou A, Livadas S, Palioura E, Economou F, Koutsilieris M, et al. Endocrine disruptors and polycystic ovary syndrome (PCOS): elevated serum levels of bisphenol A in women with PCOS. J Clin Endocrinol Metab. 2011;96:E480–E4.
Kim JH, Park HY, Bae S, Lim Y-H, Hong Y-C. Diethylhexyl phthalates is associated with insulin resistance via oxidative stress in the elderly: a panel study. PloS ONE. 2013;8:e71392.
Dong R, Zhou T, Chen J, Zhang M, Zhang H, Wu M, et al. Gender-and age-specific relationships between phthalate exposures and obesity in Shanghai adults. Arch Environ Contamination Toxicol. 2017;73:431–41.
Vafeiadi M, Myridakis A, Roumeliotaki T, Margetaki K, Chalkiadaki G, Dermitzaki E, et al. Association of early life exposure to phthalates with obesity and cardiometabolic traits in childhood: sex specific associations. Front Public Health. 2018;6:327.
Rodríguez-Carmona Y, Cantoral A, Trejo-Valdivia B, Téllez-Rojo MM, Svensson K, Peterson KE, et al. Phthalate exposure during pregnancy and long-term weight gain in women. Environ Res. 2019;169:26–32.
Yang C, Kong APS, Cai Z, Chung ACK. Persistent organic pollutants as risk factors for obesity and diabetes. Curr Diabetes Rep. 2017;17:1–11.
Clougherty JE. A growing role for gender analysis in air pollution epidemiology. Environ Health Perspect. 2010;118:167–76.
Acknowledgements
We appreciate the National Institute of Environmental Research of Korea for providing the dataset.
Funding
This study is funded by the Public Healthcare Research program by the National Medical Center of South Korea (NMC2020-PR-06) and the National Research Foundation (NRF-2018R1D1A1B07048821 and BK21 Center for Integrative Response to Health Disasters, Graduate School of Public Health, Seoul National University (NO.4199990514025)).
Author information
Authors and Affiliations
Contributions
SAC designed this study and conducted primary analysis. SK made a draft of this manuscript. WJL and HSM reviewed and revised the manuscript. All authors read and approved the final manuscript.
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Ethics approval and consent to participate
Three waves of the Korean National Environmental Health Survey were approved by the Institutional Review Board of the National Institute of Environmental Research (1st wave, Department of Environmental Epidemiology-354; 2nd wave, Department of Environmental Health Research-1805; 3rd wave, NIER-2016-BR-003-01 and NIER-2016-BR-003-03). All study participants agreed to participate the survey and signed an informed consent.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
The original online version of this article was revised: The funding section of the original article has been corrected. The NMC funding number has been changed from NMC2020-PR-00 to NMC2020-PR-06.
Supplementary information
Rights and permissions
Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Kim, S., Min, H.S., Lee, W.J. et al. Occupational differences in personal care product use and urinary concentration of endocrine disrupting chemicals by gender. J Expo Sci Environ Epidemiol 33, 312–318 (2023). https://doi.org/10.1038/s41370-022-00436-7
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41370-022-00436-7
Keywords
This article is cited by
-
Associations between lifestyle factors and levels of per- and polyfluoroalkyl substances (PFASs), phthalates and parabens in follicular fluid in women undergoing fertility treatment
Journal of Exposure Science & Environmental Epidemiology (2023)