Existing studies on the health effects of e-cigarettes focused on e-cigarette users themselves. To study the corresponding effects on passive vapers, it is crucial to quantify e-cigarette chemicals deposited in their airways.
This study proposed an innovative approach to estimate the deposited dose of e-cigarette chemicals in the passive vapers’ airways. The effect of the distance between active and passive vapers on the deposited dose was also examined.
The chemical constituent analysis was conducted to detect Nicotine and flavoring agents in e-cigarette aerosol. The Mobile Aerosol Lung Deposition Apparatus (MALDA) was employed to conduct aerosol respiratory deposition experiments in real-life settings to generate real-time data.
For e-cigarette aerosol in the ultrafine particle regime, the deposited doses in the alveolar region were on average 3.2 times higher than those in the head-to-TB airways, and the deposited dose in the passive vaper’s airways increased when being closer to the active vaper.
With prolonged exposure and close proximity to active vapers, passive vapers may be at risk for potential health effects of harmful e-cigarette chemicals. The methodology developed in this study has laid the groundwork for future research on exposure assessment and health risk analysis for passive vaping.
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Hiler M, Breland A, Spindle T, Maloney S, Lipato T, Karaoghlanian N, et al. Electronic cigarette user plasma nicotine concentration, puff topography, heart rate, and subjective effects: influence of liquid nicotine concentration and user experience. Exp Clin Psychopharmacol. 2017;25:380–92.
Dimitriadis K, Tsioufis C, Kontantinou K, Liatakis I, Andrikou E, Vogiatzakis N. et al. Acute detrimental effects of e-cigarette and tobacco cigarette smoking on blood pressure and sympathetic nerve activity in healthy subjects. Eur Heart J. 2019;40 Suppl 1:e245
Kotoulas S-C, Pataka A, Domvri K, Spyratos D, Katsaounou P, Porpodis K, et al. Acute effects of e-cigarette vaping on pulmonary function and airway inflammation in healthy individuals and in patients with asthma. Respirology. 2020;25:1037–45.
Cho JH. The association between electronic-cigarette use and self-reported oral symptoms including cracked or broken teeth and tongue and/or inside-cheek pain among adolescents: a cross-sectional study. PLoS One. 2017;12:e0180506.
Kosmider L, Sobczak A, Prokopowicz A, Kurek J, Zaciera M, Knysak J, et al. Cherry-flavoured electronic cigarettes expose users to the inhalation irritant, benzaldehyde. Thorax. 2016;71:376.
Farsalinos KE, Kistler KA, Gillman G, Voudris V. Evaluation of electronic cigarette liquids and aerosol for the presence of selected inhalation toxins. Nicotine Tob Res. 2014;17:168–74.
Gerloff J, Sundar IK, Freter R, Sekera ER, Friedman AE, Robinson R, et al. Inflammatory response and barrier dysfunction by different e-cigarette flavoring chemicals identified by gas chromatography–mass spectrometry in e-liquids and e-vapors on human lung epithelial cells and fibroblasts. Appl Vitr Toxicol. 2017;3:28–40.
Li Q, Zhan Y, Wang L, Leischow SJ, Zeng DD. Analysis of symptoms and their potential associations with e-liquids’ components: a social media study. BMC Public Health. 2016;16:674.
Omaiye EE, McWhirter KJ, Luo W, Pankow JF, Talbot P. High-nicotine electronic cigarette products: toxicity of JUUL fluids and aerosols correlates strongly with nicotine and some flavor chemical concentrations. Chem Res Toxicol. 2019;32:1058–69.
Muthumalage T, Lamb T, Friedman MR, Rahman I. E-cigarette flavored pods induce inflammation, epithelial barrier dysfunction, and DNA damage in lung epithelial cells and monocytes. Sci Rep. 2019;9:19035.
Anderson C, Majeste A, Hanus J, Wang S. E-cigarette aerosol exposure induces reactive oxygen species, DNA damage, and cell death in vascular endothelial cells. Toxicol Sci. 2016;154:332–40.
Ji EH, Sun B, Zhao T, Shu S, Chang CH, Messadi D, et al. Characterization of electronic cigarette aerosol and its induction of oxidative stress response in oral keratinocytes. PLoS One. 2016;11:e0154447.
Zhao T, Nguyen C, Lin C-H, Middlekauff HR, Peters K, Moheimani R, et al. Characteristics of secondhand electronic cigarette aerosols from active human use. Aerosol Sci Technol. 2017;51:1368–76.
Zhang L, Lin Y, Zhu Y. Transport and mitigation of exhaled electronic cigarette aerosols in a multizone indoor environment. Aerosol Air Qual Res. 2020;20:2536–47.
Zhou Y, Irshad H, Dye WW, Wu G, Tellez CS, Belinsky SA. Voltage and e-liquid composition affect nicotine deposition within the oral cavity and carbonyl formation. Tob Control Published Online First: 25 June 2020. https://doi.org/10.1136/tobaccocontrol-2020-055619.
Sosnowski TR, Kramek-Romanowska K. Predicted deposition of E-cigarette aerosol in the human lungs. J Aerosol Med Pulm Drug Deliv. 2016;29:299–309.
Su W-C, Wong S-W, Buu A. Deposition of E-cigarette aerosol in human airways through passive vaping. Indoor Air. 2021;31:348–56.
Czoli CD, Goniewicz ML, Palumbo M, Leigh N, White CM, Hammond D. Identification of flavouring chemicals and potential toxicants in e-cigarette products in Ontario, Canada. Can J Public Health. 2019;110:542–50.
Schober W, Szendrei K, Matzen W, Osiander-Fuchs H, Heitmann D, Schettgen T, et al. Use of electronic cigarettes (e-cigarettes) impairs indoor air quality and increases FeNO levels of e-cigarette consumers. Int J Hyg Environ Health. 2014;217:628–37.
Vardavas C, Girvalaki C, Vardavas A, Papadakis S, Tzatzarakis M, Behrakis P, et al. Respiratory irritants in e-cigarette refill liquids across nine European countries: a threat to respiratory health? Eur Respir J. 2017;50:1701698.
Farsalinos K, Lagoumintzis G. Toxicity classification of e-cigarette flavouring compounds based on European Union regulation: analysis of findings from a recent study. Harm Reduct J 2019;16:48.
ICRP. Human respiratory tract model for radiological protection. Publication 66. Ann ICRP. 1994;24:1–3.
Hinds WC Aerosol technology: properties, behavior, and measurement of airborne particles: John Wiley & Sons; New York, 1999.
Su W-C, Chen Y, Xi J. Estimation of the deposition of ultrafine 3D printing particles in human tracheobronchial airways. J Aerosol Sci. 2020;149:105605.
Su W-C, Chen Y, Bezerra M, Wang J. Respiratory deposition of ultrafine welding fume particles. J Occup Environ Hyg. 2019;16:694–706.
Su W-C, Chen Y, Xi J. A new approach to estimate ultrafine particle respiratory deposition. Inhal Toxicol. 2019;31:35–43.
Sassano MF, Davis ES, Keating JE, Zorn BT, Kochar TK, Wolfgang MC, et al. Evaluation of e-liquid toxicity using an open-source high-throughput screening assay. PLoS Biol. 2018;16:e2003904.
Cuddihy R, Fisher G, Kanapilly G, Moss O, Phalen R, Schlesinger R, et al. Report No. 125—deposition, retention and dosimetry of inhaled radioactive substances. NCRP; 1997.
Hammer T, Gao H, Pan Z, Wang J. Relationship between aerosols exposure and lung deposition dose. Aerosol and Air Quality. Research 2020;20:1083–93. May
Higgins ST, Heil SH, Sigmon SC, Tidey JW, Gaalema DE, Hughes JR, et al. Addiction Potential of Cigarettes With Reduced Nicotine Content in Populations With Psychiatric Disorders and Other Vulnerabilities to Tobacco Addiction. JAMA Psychiatry. 2017;74:1056–64.
Jung Y, Hsieh LS, Lee AM, Zhou Z, Coman D, Heath CJ, et al. An epigenetic mechanism mediates developmental nicotine effects on neuronal structure and behavior. Nat Neurosci. 2016;19:905–14.
Jessen A, Buemann B, Toubro S, Skovgaard IM, Astrup A. The appetite-suppressant effect of nicotine is enhanced by caffeine. Diabetes Obes Metab. 2005;7:327–33.
Leach PT, Cordero KA, Gould TJ. The effects of acute nicotine, chronic nicotine, and withdrawal from chronic nicotine on performance of a cued appetitive response. Behav Neurosci. 2013;127:303–10.
Wilens TE, Decker MW. Neuronal nicotinic receptor agonists for the treatment of attention-deficit/hyperactivity disorder: Focus on cognition. Biochem Pharm. 2007;74:1212–23.
This study was supported by R21ES031795 from the National Institute of Environmental Health Sciences (NIEHS) to W-CS; R01DA049154 from the National Institute on Drug Abuse (NIDA) to AB; and 5T42OH008421 from the National Institute for Occupational Safety and Health (NIOSH) to the Southwest Center for Occupational and Environmental Health (SWCOEH).
The authors declare no competing interests.
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
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Su, WC., Lin, YH., Wong, SW. et al. Estimation of the dose of electronic cigarette chemicals deposited in human airways through passive vaping. J Expo Sci Environ Epidemiol 31, 1008–1016 (2021). https://doi.org/10.1038/s41370-021-00362-0
- E-cigarette, Aerosol, Human airways, Respiratory deposition, Deposited dose
BMC Public Health (2022)