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Spatio-temporal assessment of pregnant women exposure to chlorpyrifos at a regional scale

Journal of Exposure Science & Environmental Epidemiology volume 32, pages 156–168 (2022)Cite this article

Abstract

Background

The aim of this study was to use an integrated exposure assessment approach, combining spatiotemporal modeling of environmental exposure and fate of the chemical to assess the exposure of vulnerable populations. In this study, chlorpyrifos exposure of pregnant women in Picardy was evaluated at a regional scale during 1 year. This approach provided a mapping of exposure indicators of pregnant women to chlorpyrifos over fine spatial and temporal resolutions using a GIS environment.

Methods

Fate and transport models (emission, atmospheric dispersion, multimedia exposure, PBPK) were combined with environmental databases in a GIS environment. Quantities spread over agricultural fields were simulated and integrated into a modeling chain coupling models. The fate and transport of chlorpyrifos was characterized by an atmospheric dispersion statistical metamodel and the dynamiCROP model. Then, the multimedia model Modul’ERS was used to predict chlorpyrifos daily exposure doses which were integrated in a PBPK model to compute biomarker of exposure (TCPy urinary concentrations). For the concentration predictions, two scenarios (lower bound and upper bound) were built.

Results

At fine spatio-temporal resolutions, the cartography of biomarkers in the lower bound scenario clearly highlights agricultural areas. In these maps, some specific areas and hotspots appear as potentially more exposed specifically during application period. Overall, predictions were close to biomonitoring data and ingestion route was the main contributor to chlorpyrifos exposure.

Conclusions

This study demonstrated the feasibility of an integrated approach for the evaluation of chlorpyrifos exposure which allows the comparison between modeled predictions and biomonitoring data.

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Fig. 1: Conceptual scheme of the modeling approach used in this study.
Fig. 2: Seasonality of chlorpyrifos spreading in Picardy.
Fig. 3: Mapping of daily exposure doses for the inhalation and ingestion pathways for pregnant women in Picardy.
Fig. 4: Mapping of urinary concentrations of TCPy for pregnant women in Picardy.
Fig. 5: Mean contributions of exposure pathways to aggregated TCPy urinary concentrations.

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Acknowledgements

The authors would like to thank Dr. Peter Fantke from the Technical University of Denmark (DTU) for courteously providing them the dynamiCROP model. They would like to thank Dr. Torka S. Poet from Battelle Pacific Northwest Division for providing them the PBPK model of chlorpyrifos. They also would like to thank Christian Dersigny from Oise Agricultural Chamber for providing spreading times for chlorpyrifos.

Funding

This research was funded by the French minister in charge of the environment and by the French Biodiversity Agency (Agence française de la biodiversité—AFB) into the Ecophyto 2 plan context.

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Authors and Affiliations

  1. Institut National de l’Environnement Industriel et des Risques (INERIS), Unité Impact Sanitaire et Exposition (ISAE), Parc ALATA BP2, 60550, Verneuil-en-Halatte, France

    Corentin Regrain, Roseline Bonnard, Emmanuelle Boulvert & Julien Caudeville

  2. LAMFA, UMR CNRS 7352, Université de Picardie Jules Verne, 33 rue Saint-Leu, 80039, Amiens, France

    Corentin Regrain & Mohammed Guedda

  3. PériTox (UMR_I 01), INERIS/UPJV, Institut National de l’Environnement Industriel et des Risques (INERIS), Verneuil-en-Halatte, France

    Corentin Regrain & Julien Caudeville

  4. Institut National de l’Environnement Industriel et des Risques (INERIS), Unité Toxicologie Expérimentale et Modélisation (TEAM), Parc ALATA BP2, 60550, Verneuil-en-Halatte, France

    Florence Anna Zeman & Céline Brochot

  5. PériTox (UMR_I 01), UPJV/INERIS, UPJV, Amiens, France

    Karen Chardon & Véronique Bach

  6. Institut National de l’Environnement Industriel et des Risques (INERIS), Unité Modélisation Atmosphérique et Cartographie Environnementale (MOCA), Parc ALATA BP2, 60550, Verneuil-en-Halatte, France

    Frédéric Tognet

  7. Institut National de l’Environnement Industriel et des Risques (INERIS), Unité Instrumentation et Exploitation de la Donnée (INDO), Parc ALATA BP2, 60550, Verneuil-en-Halatte, France

    Laure Malherbe & Laurent Létinois

  8. Institut National de l’Environnement Industriel et des Risques (INERIS), Unité Accompagnement à la surveillance de la qualité de l’air et des eaux de surfaces (ASUR), Parc ALATA BP2, 60550, Verneuil-en-Halatte, France

    Fabrice Marlière

  9. Institut National de l’Environnement Industriel et des Risques (INERIS), Unité Méthodes & Développements en Analyses pour l’Environnement (ANAE), Parc ALATA BP2, 60550, Verneuil-en-Halatte, France

    François Lestremau

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Regrain, C., Zeman, F.A., Guedda, M. et al. Spatio-temporal assessment of pregnant women exposure to chlorpyrifos at a regional scale. J Expo Sci Environ Epidemiol 32, 156–168 (2022). https://doi.org/10.1038/s41370-021-00315-7

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