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Correlates of exposure to phenols, parabens, and triclocarban in the Study of Environment, Lifestyle and Fibroids

Journal of Exposure Science & Environmental Epidemiology volume 30, pages 117–136 (2020)Cite this article

Abstract

We performed a cross-sectional analysis to identify correlates of urinary concentrations of seven phenols (bisphenols A, F, and S; 2,4-dichlorophenol; 2,5-dichlorophenol; benzophenone-3; triclosan), triclocarban, and four parabens (butyl, ethyl, methyl, and propyl). We analyzed baseline data from 766 participants in the Study of Environment, Lifestyle, and Fibroids, a prospective cohort study of 1693 Black women aged 23–34 years residing in Detroit, Michigan (2010–2012). We collected data on demographic, behavioral, and anthropometric factors via telephone interviews, clinic visits, and self-administered questionnaires. For each biomarker, we used linear regression models to estimate mean differences in log-transformed, creatinine-corrected concentrations across factors of interest. Each biomarker was detected in >50% of participants. Median creatinine-corrected concentrations were the highest for methyl paraben (116.8 μg/g creatinine), propyl paraben (16.8 μg/g creatinine), and benzophenone-3 (13.4 μg/g creatinine). Variables most strongly associated with biomarker concentrations included season of urine collection, education, and body mass index (BMI). BMI was positively associated with bisphenol A and S and triclocarban concentrations and inversely associated with butyl and methyl paraben concentrations. In this cohort of Black women, exposure to phenols, parabens, and triclocarban was prevalent and several factors were associated with biomarker concentrations.

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Acknowledgements

This research was funded by the National Institute of Environmental Health Sciences (R01ES024749 and Intramural Research Program) and the American Recovery and Reinvestment Act. The authors wish to thank Prabha Dwivedi, Xiaoliu Zhou, and Tao Jia for the quantification of the chemical biomarkers, as well as Ganesa Wegienka, Birgit Claus Henn, Hanna Gerlovin, and Alexandra McHale for technical assistance. We also thank Gregory Travlos and Ralph Wilson (NIEHS, Clinical Pathology Core) for the quantification of creatinine.

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  1. Deceased: Xiaoyun Ye

Authors and Affiliations

  1. Slone Epidemiology Center at Boston University, Boston, MA, USA

    Traci N. Bethea

  2. Department of Medicine, Boston University School of Medicine, Boston, MA, USA

    Traci N. Bethea

  3. Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA

    Amelia K. Wesselink, Jennifer Weuve & Lauren A. Wise

  4. Department of Environmental Health, Boston University School of Public Health, Boston, MA, USA

    Michael D. McClean

  5. Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA

    Russ Hauser

  6. Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA

    Paige L. Williams

  7. National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA

    Xiaoyun Ye & Antonia M. Calafat

  8. Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA

    Donna D. Baird

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Bethea, T.N., Wesselink, A.K., Weuve, J. et al. Correlates of exposure to phenols, parabens, and triclocarban in the Study of Environment, Lifestyle and Fibroids. J Expo Sci Environ Epidemiol 30, 117–136 (2020). https://doi.org/10.1038/s41370-019-0114-9

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  • DOI: https://doi.org/10.1038/s41370-019-0114-9

Keywords

  • Endocrine disruptors
  • Epidemiology
  • Personal exposure
  • Population-based studies

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