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Long-term exposure to ambient air pollution and renal function in African Americans: the Jackson Heart Study

Abstract

Renal dysfunction is prevalent in the US among African Americans. Air pollution is associated with renal dysfunction in mostly white American populations, but has not been studied among African Americans. We evaluated cross-sectional associations between 1-year and 3-year fine particulate matter (PM2.5) and ozone (O3) concentrations, and renal function among 5090 African American participants in the Jackson Heart Study. We used mixed-effect linear regression to estimate associations between 1-year and 3-year PM2.5 and O3 and estimated glomerular filtration rate (eGFR), urine albumin/creatinine ratio (UACR), serum creatinine, and serum cystatin C, adjusting for: sociodemographic factors, health behaviors, and medical history and accounting for clustering by census tract. At baseline, JHS participants had mean age 55.4 years, and 63.8% were female; mean 1-year and 3-year PM2.5 concentrations were 12.2 and 12.4 µg/m3, and mean 1-year and 3-year O3 concentrations were 40.2 and 40.7 ppb, respectively. Approximately 6.5% of participants had reduced eGFR (< 60 mL/min/1.73m2) and 12.7% had elevated UACR (> 30 mg/g), both indicating impaired renal function. Annual and 3-year O3 concentrations were inversely associated with eGFR and positively associated with serum creatinine; annual and 3-year PM2.5 concentrations were inversely associated with UACR. We observed impaired renal function associated with increased O3 but not PM2.5 exposure among African Americans.

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Acknowledgements

The Jackson Heart Study is supported and conducted in collaboration with Jackson State University (HHSN268201300049C, HHSN268201300050C), Tougaloo College (HHSN268201300049C), and the University of Mississippi Medical Center (HHSN268201300046C, HHSN268201300047C) contracts from the National Heart, Lung, and Blood Institute and the National Institute on Minority Health and Health Disparities. The authors thank the participants and staffs of the JHS.

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The views expressed in this paper are those of the authors, and do not necessarily represent the views of the National Heart, Lung, and Blood Institute; the National Institutes of Health; the U.S. Department of Health and Human Services.

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Correspondence to Yi Wang.

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Weaver, A.M., Wang, Y., Wellenius, G.A. et al. Long-term exposure to ambient air pollution and renal function in African Americans: the Jackson Heart Study. J Expo Sci Environ Epidemiol 29, 548–556 (2019). https://doi.org/10.1038/s41370-018-0092-3

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Key words

  • Renal
  • eGFR
  • particulate matter
  • ozone

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