Evaluation of the relationship between residential orchard density and dimethyl organophosphate pesticide residues in house dust


Reducing residential pesticide exposure requires identification of exposure pathways. Compared to the agriculture worker ‘take-home’ and residential use pathways, evidence of the ‘drift’ pathway to pesticide exposure has been inconsistent. Questionnaire data from individuals (n = 99) and dust samples (n = 418) from households across three growing seasons in 2011 were from the For Healthy Kids! study. Summed dimethyl organophosphate pesticide (OP) (Azinphos-Methyl, Phosmet, and Malathion) concentrations were quantified from house dust samples. Spatially-weighted orchard densities surrounding households were calculated based on various distances from homes. Regression models tested associations between orchard density, residential pesticide use, agriculture worker residents, and summed dimethyl OP house dust concentrations. Estimated relationships between orchard density and dimethyl OP in house dust were mixed: a 5% increase in orchard density resulted in 0.3 and 0.5% decreases in dimethyl OP house dust concentrations when considering land-cover 750 m or 1250 m away from households, respectively, but null associations with land-cover 60 m or 200 m away. Dimethyl OP house dust concentrations were 400% higher within homes where at least two residents were agriculture workers. Despite inconclusive evidence for the drift pathway due to potential for bias, relationships between number of agriculture workers and dimethyl OP house dust concentration underscores the take-home pathway.

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  1. 1.

    Alavanja MC, Sandler DP, McDonnell CJ, Lynch CF, Pennybacker M, Zahm SH, et al. Characteristics of pesticide use in a pesticide applicator cohort: the Agricultural Health Study. Environ Res. 1999;80:172–9.

    CAS  Article  Google Scholar 

  2. 2.

    Almberg KS, Turyk M, Jones RM, Anderson R, Graber J, Banda E, et al. A study of adverse birth outcomes and agricultural land use practices in Missouri. Environ Res. 2014;134:420–6.

    CAS  Article  Google Scholar 

  3. 3.

    Alarcon WA, Calvert GM, Blondell JM, Mehler LN, Sievert J, Propeck M, et al. Acute illnesses associated with pesticide exposure at schools. JAMA. 2005;294:455–65.

    CAS  Article  Google Scholar 

  4. 4.

    Rothlein J, Rohlman D, Lasarev M, Phillips J, Muniz J, McCauley L Organophosphate pesticide exposure and neurobehavioral performance in agricultural and nonagricultural Hispanic workers. Environ Health Perspect. 2006;5:691–6.

    CAS  Article  Google Scholar 

  5. 5.

    Rohlman DS, Arcury TA, Quandt SA, Lasarev M, Rothlein J, Travers R, et al. Neurobehavioral performance in preschool children from agricultural and non-agricultural communities in Oregon and North Carolina. Neurotoxicology. 2005;26:589–98.

    Article  Google Scholar 

  6. 6.

    Bradman A, Quirs-Alcal L, Castorina R, Schall RA, Camacho J, Holland NT, et al. Effect of organic diet intervention on pesticide exposures in young children living in low-income urban and agricultural communities. Environ Health Perspect. 2015;123:1086.

    CAS  Article  Google Scholar 

  7. 7.

    Thompson B, Coronado GD, Vigoren EM, Griffith WC, Fenske RA, Kissel JC, et al. Para niños saludables: a community intervention trial to reduce organophosphate pesticide exposure in children of farmworkers. Environ Health Perspect. 2008;116:687.

    CAS  Article  Google Scholar 

  8. 8.

    Deziel NC, Friesen MC, Hoppin JA, Hines CJ, Thomas K, Freeman LE. A review of nonoccupational pathways for pesticide exposure in women living in agricultural areas. Environ Health Perspect. 2015;123:515–24.

    CAS  Article  Google Scholar 

  9. 9.

    Quandt SA, Hernndez-Valero MA, Grzywacz JG, Hovey JD, Gonzales M, Arcury TA. Workplace, household, and personal predictors of pesticide exposure for farmworkers. Environ Health Perspect. 2006;6:943–52.

    CAS  Article  Google Scholar 

  10. 10.

    Arcury TA, Grzywacz JG, Barr DB, Tapia J, Chen H, Quandt SA Pesticide urinary metabolite levels of children in eastern North Carolina farmworker households. Environ Health Perspect. 2007;8:1254–60.

    CAS  Article  Google Scholar 

  11. 11.

    Fenske RA, Lu C, Barr D, Needham L. Children's exposure to chlorpyrifos and parathion in an agricultural community in central Washington State. Environ Health Perspect. 2002;110:549–53.

    CAS  Article  Google Scholar 

  12. 12.

    Morgan MK, Stout IDM, Wilson NK. Feasibility study of the potential for human exposure to pet-borne diazinon residues following lawn applications. Bull Environ Contam Toxicol. 2001;66:295–300.

    CAS  Article  Google Scholar 

  13. 13.

    Thompson B, Griffith WC, Barr DB, Coronado GD, Vigoren EM, Faustman EM. Variability in the take-home pathway: farmworkers and non-farmworkers and their children. J Exp Sci Environ Epidemiol. 2014;5:522–31.

    Article  Google Scholar 

  14. 14.

    Thompson B, Coronado GD, Grossman JE, Puschel K, Solomon CC, Islas I, et al. Pesticide take-home pathway among children of agricultural workers: study design, methods, and baseline findings. J Occup Environ Med. 2003;45:42–53.

    Article  Google Scholar 

  15. 15.

    Lu C, Fenske RA, Simcox NJ, Kalman D. Pesticide exposure of children in an agricultural community: evidence of household proximity to farmland and take home exposure pathways. Environ Res. 2000;84:290–302.

    CAS  Article  Google Scholar 

  16. 16.

    McCauley LA, Anger WK, Keifer M, Langley R, Robson MG, Rohlman D Studying health outcomes in farmworker populations exposed to pesticides. Environ Health Perspect 2006;6:953–60.

    CAS  Article  Google Scholar 

  17. 17.

    Simcox NJ, Fenske RA, Wolz SA, Lee I, Kalman DA. Pesticides in household dust and soil: exposure pathways for children of agricultural families. Environ Health Perspect. 1995;103:1126.

    CAS  Article  Google Scholar 

  18. 18.

    Richards SM, McClure G, Lavy TL, Mattice JD, Keller RJ, Gandy J. Propanil (3, 4-dichloropropionanilide) particulate concentrations within and near the residences of families living adjacent to aerially sprayed rice fields. Arch Environ Contam Toxicol. 2001;41:112–6.

    CAS  Article  Google Scholar 

  19. 19.

    Coronado GD, Holte S, Vigoren E, Griffith WC, Faustman E, Thompson B. Organophosphate pesticide exposure and residential proximity to nearby fields: evidence for the drift pathway. J Occup Environ Med/Am Coll Occup Environ Med. 2011;53:884.

    CAS  Article  Google Scholar 

  20. 20.

    Golla V, Curwin B, Sanderson W, Nishioka M. Pesticide concentrations in vacuum dust from farm homes: variation between planting and nonplanting seasons. ISRN Public Health. 2012; Article ID 539397: 10 pages.

  21. 21.

    Lozier MJ, Curwin B, Nishioka MG, Sanderson W. Determinants of atrazine contamination in the homes of commercial pesticide applicators across time. J Occup Environ Hyg. 2012;9:289–97.

    CAS  Article  Google Scholar 

  22. 22.

    Bradman A, Schwartz JM, Fenster L, Barr DB, Holland NT, Eskenazi B. Factors predicting organochlorine pesticide levels in pregnant Latina women living in a United States agricultural area. J Expo Sci Environ Epidemiol. 2007;17:388–99.

    CAS  Article  Google Scholar 

  23. 23.

    Huen K, Bradman A, Harley K, Yousefi P, Barr DB, Eskenazi B, et al. Organophosphate pesticide levels in blood and urine of women and newborns living in an agricultural community. Environ Res. 2012;117:8–16.

    CAS  Article  Google Scholar 

  24. 24.

    Alexander BH, Mandel JS, Baker BA, Burns CJ, Bartels MJ, Acquavella JF, et al. Biomonitoring of 2, 4-dichlorophenoxyacetic acid exposure and dose in farm families. Environ Health Perspect. 2007;3:370–6.

    CAS  Article  Google Scholar 

  25. 25.

    Acquavella JF, Alexander BH, Mandel JS, Gustin C, Baker B, Chapman P, et al. Glyphosate biomonitoring for farmers and their families: results from the Farm Family Exposure Study. Environ Health Perspect. 2004;112:321.

    CAS  Article  Google Scholar 

  26. 26.

    Gunier RB, Ward MH, Airola M, Bell EM, Colt J, Nishioka M, et al. Determinants of agricultural pesticide concentrations in carpet dust. Environ Health Perspect. 2011;119:970–6.

    CAS  Article  Google Scholar 

  27. 27.

    Deziel NC, Ward MH, Bell EM, Whitehead TP, Gunier RB, Friesen MC, et al. Temporal variability of pesticide concentrations in homes and implications for attenuation bias in epidemiologic studies. Environ Health Perspect (Online). 2013;121:565.

    Article  Google Scholar 

  28. 28.

    Harnly ME, Bradman A, Nishioka M, McKone TE, Smith D, McLaughlin R, et al. Pesticides in dust from homes in an agricultural area. Environ Sci Technol. 2009;43:8767–74.

    CAS  Article  Google Scholar 

  29. 29.

    Ward MH, Lubin J, Giglierano J, Colt JS, Wolter C, Bekiroglu N, et al. Proximity to crops and residential exposure to agricultural herbicides in Iowa. Environ Health Perspect 2006;6:893–7.

    CAS  Article  Google Scholar 

  30. 30.

    Curwin BD, Hein MJ, Sanderson WT, Nishioka MG, Reynolds SJ, Ward EM, et al. Pesticide contamination inside farm and nonfarm homes. J Occup Environ Hyg. 2005;2:357–67.

    CAS  Article  Google Scholar 

  31. 31.

    Weppner S, Elgethun K, Lu C, Hebert V, Yost MG, Fenske RA. The Washington aerial spray drift study: children's exposure to methamidophos in an agricultural community following fixed-wing aircraft applications. J Expo Sci Environ Epidemiol. 2006;16:387–96.

    CAS  Article  Google Scholar 

  32. 32.

    Smith MN, Wilder CS, Griffith WC, Workman T, Thompson B, Dills R, et al. Seasonal variation in cortisol biomarkers in Hispanic mothers living in an agricultural region. Biomarkers. 2015;20:299–305.

    CAS  Article  Google Scholar 

  33. 33.

    U.S. Department of Agriculture. National Agricultural Statistics Service, Washington. CropScape-cropland data layer. 2011; Available at: http://nassgeodata.gmu.edu/CropScape. Accessed July 7, 2016.

  34. 34.

    Boryan C, Yang Z, Mueller R, Craig M. Monitoring US agriculture: the US Department of Agriculture, National Agricultural Statistics Service, Cropland Data Layer Program. Geocarto Int. 2011;26:341–58.

    Article  Google Scholar 

  35. 35.

    Rothman KJ, Greenland S, Lash TL. Modern epidemiology. 3rd edn. Wolters Kluwer Health/Lippincott Williams & Wilkins: Philadelphia, 2008.

  36. 36.

    Baddeley A, Rubak E, Turner R. Spatial point patterns: methodology and applications with R. CRC Press: New York, 2015.

  37. 37.

    Baddeley A, Turner R Package ‘spatstat’. 2015.

  38. 38.

    Coronado GD, Griffith WC, Vigoren EM, Faustman EM, Thompson B. Where’s the dust? Characterizing locations of azinphos-methyl residues in house and vehicle dust among farmworkers with young children. J Occup Environ Hyg. 2010;7:663–71.

    Article  Google Scholar 

  39. 39.

    Griffith W, Curl CL, Fenske RA, Lu CA, Vigoren EM, Faustman EM. Organophosphate pesticide metabolite levels in pre-school children in an agricultural community: within-and between-child variability in a longitudinal study. Environ Res. 2011;111:751–6.

    CAS  Article  Google Scholar 

  40. 40.

    Lunn D, Jackson C, Best N, Thomas A, Spiegelhalter D The BUGS book: a practical introduction to Bayesian analysis. CRC press, 2012.

  41. 41.

    Lunn DJ, Thomas A, Best N, Spiegelhalter D. WinBUGS-a Bayesian modelling framework: concepts, structure, and extensibility. Stat Comput. 2000;10:325–37.

    Article  Google Scholar 

  42. 42.

    Costa LG, Giordano G, Guizzetti M, Vitalone A. Neurotoxicity of pesticides: a brief review. Front Biosci. 2008;13:1240–9.

    CAS  Article  Google Scholar 

  43. 43.

    Shaffer RM, Smith MN, Faustman EM. Developing the Regulatory Utility of the Exposome: Mapping Exposures for Risk Assessment through Lifestage Exposome Snapshots (LEnS). Environ Health Perspect. 2017;125:085003.

    Article  Google Scholar 

  44. 44.

    Iyyadurai R, Peter JV, Immanuel S, Begum A, Zachariah A, Jasmine S, et al. Organophosphate-pyrethroid combination pesticides may be associated with increased toxicity in human poisoning compared to either pesticide alone. Clin Toxicol. 2014;52:538–41.

    CAS  Article  Google Scholar 

  45. 45.

    Sas Institute. SAS/STAT 9.4 user’s guide. SAS Institute, 2014.

  46. 46.

    McCauley LA, Lasarev MR, Higgins G, Rothlein J, Muniz J, Ebbert C, et al. Work characteristics and pesticide exposures among migrant agricultural families: a community-based research approach. Environ Health Perspect. 2001;109:533.

    CAS  Article  Google Scholar 

  47. 47.

    Brunner, E. 2014. School quality, school choice and residential mobility. In Education, land and location, eds. G. K. Ingram and D. A. Kenyon, 62–87. Cambridge, UK: Lincoln Institute of Land Policy.

  48. 48.

    Martinez VJ, Godwin RK, Kemerer FR, Perna L The consequences of school choice: Who leaves and who stays in the inner city. Social Science Quarterly 1995;3:485-501.

  49. 49.

    Sampson RJ. Moving to inequality: Neighborhood effects and experiments meet structure. Am J Sociol. 2008;114:189.

    Article  Google Scholar 

  50. 50.

    Gibbs JL, Yost MG, Negrete M, Fenske RA. Passive sampling for indoor and outdoor exposures to chlorpyrifos, azinphos-methyl, and oxygen analogs in a rural agricultural community. Environ Health Perspect. 2017;125:333.

    CAS  Article  Google Scholar 

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This work was prepared with the support of a grant funded by NIEHS and the EPA (P01ES009601 and R826886; PI: Elaine Faustman. Dr. Plascak was supported by a grant from NCI (R25CA092408) during this work. Neither funding agency is responsible for the content of this article. We wish to thank all the individuals who participated in this study as well as staff from the Community Center for Health Promotion who collected the data and interacted with the participants.

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Correspondence to Jesse J. Plascak.

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Plascak, J.J., Griffith, W.C., Workman, T. et al. Evaluation of the relationship between residential orchard density and dimethyl organophosphate pesticide residues in house dust. J Expo Sci Environ Epidemiol 29, 379–388 (2019). https://doi.org/10.1038/s41370-018-0074-5

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  • Density Orchards
  • House Dust Samples
  • Drift Pathways
  • Residual Pesticides
  • Phosmet

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