Temporal trends and developmental patterns of plasma polybrominated diphenyl ether concentrations over a 15-year period between 1998 and 2013


Polybrominated diphenyl ethers (PBDEs) were used extensively as flame retardants in furniture containing polyurethane foam until they were phased out of use, beginning in 2004. We examined temporal changes in plasma PBDE concentrations from 1998 to 2013 and characterized patterns of exposure over the early lifecourse among 334 children (903 samples) between birth and 9 years. We examined time trends by regressing PBDE concentration on year of sample collection in age-adjusted models and characterized developmental trajectories using latent class growth analysis (LCGA). Controlling for age, BDE-47 concentrations decreased 5% (95% confidence interval (CI): −9, −2) per year between 1998 and 2013. When considering only postnatal samples, this reduction strengthened to 13% (95% CI: −19, −9). Findings for BDE-99, 100 and 153 were similar, except that BDE-153 decreased to a lesser extent when both prenatal and postnatal samples were considered (−2%, 95% CI: −7, 0). These findings suggest that, on average, pentaBDE body burdens have decreased since the 2004 phase-out of these chemicals. When examining developmental period, PBDE concentrations peaked during toddler years for the majority of children, however, our observation of several unique trajectories suggests that a single measure may not accurately reflect exposure to PBDEs throughout early life.

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  1. 1.

    Callahan P, Roe S, Hawthorne M Playing with Fire. Chicago Tribune, Chicago, IL, USA, 2012.

  2. 2.

    Cal-117. Requirements, test procedure and apparatus for testing the flame retardance of resilient filling materials used in upholstered furniture (Technical Bulletin 117). In: FurnishingsCBoTIaH (eds) [Modified 1990], 1975.

  3. 3.

    EPA. An exposure assessment of polybrominated diphenyl ethers. In: Assessment National Center for Environmental Assessment Office of Research and Development (ed). Washington, DC: Environmental Protection Agency, 2010. EPA/600/R-08/086F.

  4. 4.

    Corportation GLC. Great Lakes Chemical Corporation completes phase-out of two flame retardants. Indianapolic, IN: Great Lakes Chemical Corportation; 2005. In.

  5. 5.

    EPA. DecaBDE Phase-out Initiative. Washington D.C., United States: United States Environmental Protection Agency: Chemical Safety and Pollution Prevention; 2015.

  6. 6.

    Fromme H, Becher G, Hilger B, Volkel W. Brominated flame retardants - Exposure and risk assessment for the general population. Int J Hyg Environ Health. 2016;219:1–23.

  7. 7.

    Linares V, Belles M, Domingo JL. Human exposure to PBDE and critical evaluation of health hazards. Arch Toxicol. 2015;89:335–56.

  8. 8.

    Talsness CE. Overview of toxicological aspects of polybrominated diphenyl ethers: a flame-retardant additive in several consumer products. Environ Res. 2008;108:158–67.

  9. 9.

    UNEP. United Nations Environment Programme. Technical review of the implications of reclycling commercial Penta and Octabromodiphenyl ethers., 2010.

  10. 10.

    Alcock RE, Sweetman AJ, Prevedouros K, Jones KC. Understanding levels and trends of BDE-47 in the UK and North America: an assessment of principal reservoirs and source inputs. Environ Int. 2003;29:691–8.

  11. 11.

    Hites RA. Polybrominated diphenyl ethers in the environment and in people: a meta-analysis of concentrations. Environ Sci Technol. 2004;38:945–56.

  12. 12.

    Cobb D. Analysis of FR chemicals added to foams, fabric, batting, loose fill and barriers. Memorandum to Dale R Ray, Project Manager, Upholstered Furniture, Consumer Products Safety Commission 2005.

  13. 13.

    Abbasi G, Buser AM, Soehl A, Murray MW, Diamond ML. Stocks and flows of PBDEs in products from use to waste in the U.S. and Canada from 1970 to 2020. Environ Sci Technol. 2015;49:1521–8.

  14. 14.

    Zhang X, Diamond ML, Robson M. Harrad S Sources, emissions, and fate of polybrominated diphenyl ethers and polychlorinated biphenyls indoors in Toronto, Canada. Environ Sci Technol. 2011;45:3268–74.

  15. 15.

    Frederiksen M, Vorkamp K, Thomsen M, Knudsen LE. Human internal and external exposure to PBDEs--a review of levels and sources. Int J Hyg Environ Health. 2009;212:109–34.

  16. 16.

    Lorber M. Exposure of Americans to polybrominated diphenyl ethers. J Expo Sci Environ Epidemiol. 2008;18:2–19.

  17. 17.

    ATSDR. Toxicological profile for polybrominated biphenyls and polybrominated diphenyl ethers (PBDEs). In: Registry AfTSD, (ed). Atlanta, GA, 2017.

  18. 18.

    Dassanayake RM, Wei H, Chen RC, Li A. Optimization of the matrix solid phase dispersion extraction procedure for the analysis of polybrominated diphenyl ethers in human placenta. Anal Chem. 2009;81:9795–801.

  19. 19.

    Fang J, Nyberg E, Winnberg U, Bignert A, Bergman A. Spatial and temporal trends of the Stockholm Convention POPs in mothers’ milk -- a global review. Environ Sci Pollut Res Int. 2015;22:8989–9041.

  20. 20.

    Geyer H, Schramm K, Darnerud P, Aune M, Feicht E, Fried K. Terminal elimination half-lives of the brominated flame retardants TBBPA, HBCD, and lower brominated PBDEs in humans. Organomet Comp. 2004;66:5.

  21. 21.

    Lunder S, Hovander L, Athanassiadis I, Bergman A. Significantly higher polybrominated diphenyl ether levels in young U.S. children than in their mothers. Environ Sci Technol. 2010;44:5256–62.

  22. 22.

    Hoffman K, Webster TF, Sjodin A, Stapleton HM. Toddler’s behavior and its impacts on exposure to polybrominated diphenyl ethers. J Expo Sci Environ Epidemiol. 2017;27:193–7.

  23. 23.

    Hurley S, Goldberg D, Nelson DO, Guo W, Wang Y, Baek HG, et al. Temporal Evaluation of Polybrominated Diphenyl Ether (PBDE) Serum Levels in Middle-Aged and Older California Women, 2011-5. Environ Sci Technol. 2017;51:4697–704.

  24. 24.

    Sjodin A, Schecter A, Jones R, Wong LY, Colacino JA, Malik-Bass N, et al. Polybrominated diphenyl ethers, 2,2’,4,4’,5,5’-hexachlorobiphenyl (PCB-153), and p,p’-dichlorodiphenyldichloroethylene (p,p’-DDE) concentrations in sera collected in 2009 from Texas children. Environ Sci Technol. 2014;48:8196–202.

  25. 25.

    Toms LM, Sjodin A, Harden F, Hobson P, Jones R, Edenfield E, et al. Serum polybrominated diphenyl ether (PBDE) levels are higher in children (2-5 years of age) than in infants and adults. Environ Health Perspect. 2009;117:1461–5.

  26. 26.

    Zota AR, Linderholm L, Park JS, Petreas M, Guo T, Privalsky ML, et al. Temporal comparison of PBDEs, OH-PBDEs, PCBs, and OH-PCBs in the serum of second trimester pregnant women recruited from San Francisco General Hospital, California. Environ Sci Technol. 2013;47:11776–84.

  27. 27.

    Perera FP, Rauh V, Whyatt RM, Tsai WY, Tang D, Diaz D, et al. Effect of prenatal exposure to airborne polycyclic aromatic hydrocarbons on neurodevelopment in the first 3 years of life among inner-city children. Environ Health Perspect. 2006;114:1287–92.

  28. 28.

    Mayer S, Jencks C. Poverty and the distribition of material hardship. J Hum Resour. 1988;24:88–114.

  29. 29.

    Jones R, Edenfield E, Anderson S, Zhang Y, Sjodin A. Semi-automated extraction and cleanup method for measuring persistent organic pollutants in human serum. Organomet Comp. 2012;74:97–98.

  30. 30.

    Sjodin A, Jones RS, Lapeza CR, Focant JF, McGahee EE 3rd, Patterson DG Jr.. Semiautomated high-throughput extraction and cleanup method for the measurement of polybrominated diphenyl ethers, polybrominated biphenyls, and polychlorinated biphenyls in human serum. Anal Chem. 2004;76:1921–7.

  31. 31.

    Phillips DL, Pirkle JL, Burse VW, Bernert JT Jr., Henderson LO, Needham LL. Chlorinated hydrocarbon levels in human serum: effects of fasting and feeding. Arch Environ Contam Toxicol. 1989;18:495–500.

  32. 32.

    Cowell WJ, Sjodin A, Jones R, Wang Y, Wang S, Herbstman JB. Determinants of prenatal exposure to polybrominated diphenyl ethers (PBDEs) among urban, minority infants born between 1998-2006. Environ Pollut. 2018;223:774–81.

  33. 33.

    Baccarelli A, Pfeiffer R, Consonni D, Pesatori AC, Bonzini M, Patterson DG Jr, et al. Handling of dioxin measurement data in the presence of non-detectable values: overview of available methods and their application in the Seveso chloracne study. Chemosphere. 2005;60:898–906.

  34. 34.

    Nagin DS. Group-based trajectory modeling: an overview. Ann Nutr Metab. 2014;65:205–10.

  35. 35.

    Jones B, Nagin D. KA R SAS procedure based on mixture models for estimating developmental trajectories. Sociol Methodol Res. 2001;29:374–93.

  36. 36.

    Nagin D. Group-based modeling of development.. Cambridge, Massachusetts: Harvard University Press; 2005.

  37. 37.

    Castorina R, Bradman A, Sjodin A, Fenster L, Jones RS, Harley KG, et al. Determinants of serum polybrominated diphenyl ether (PBDE) levels among pregnant women in the CHAMACOS cohort. Environ Sci Technol. 2011;45:6553–60.

  38. 38.

    Eskenazi B, Chevrier J, Rauch SA, Kogut K, Harley KG, Johnson C, et al. In utero and childhood polybrominated diphenyl ether (PBDE) exposures and neurodevelopment in the CHAMACOS study. Environ Health Perspect. 2013;121:257–62.

  39. 39.

    Sagiv SK, Kogut K, Gaspar FW, Gunier RB, Harley KG, Parra K, et al. Prenatal and childhood polybrominated diphenyl ether (PBDE) exposure and attention and executive function at 9-12 years of age. Neurotoxicol Teratol. 2015;52:151–61.

  40. 40.

    Vuong AM, Braun JM, Yolton K, Xie C, Webster GM, Sjodin A, et al. Prenatal and postnatal polybrominated diphenyl ether exposure and visual spatial abilities in children. Environ Res. 2017;153:83–92.

  41. 41.

    Vuong AM, Webster GM, Romano ME, Braun JM, Zoeller RT, Hoofnagle AN, et al. Maternal polybrominated diphenyl ether (PBDE) exposure and thyroid hormones in maternal and cord sera: The HOME Study, Cincinnati, USA. Environ Health Perspect. 2015;123:1079–85.

  42. 42.

    Gump BB, Yun S, Kannan K. Polybrominated diphenyl ether (PBDE) exposure in children: possible associations with cardiovascular and psychological functions. Environ Res. 2014;132:244–50.

  43. 43.

    Herbstman JB, Sjodin A, Apelberg BJ, Witter FR, Patterson DG, Halden RU, et al. Determinants of prenatal exposure to polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) in an urban population. Environ Health Perspect. 2007;115:1794–1800.

  44. 44.

    Herbstman JB, Sjodin A, Kurzon M, Lederman SA, Jones RS, Rauh V, et al. Prenatal exposure to PBDEs and neurodevelopment. Environ Health Perspect. 2010;118:712–9.

  45. 45.

    Horton MK, Bousleiman S, Jones R, Sjodin A, Liu X, Whyatt R, et al. Predictors of serum concentrations of polybrominated flame retardants among healthy pregnant women in an urban environment: a cross-sectional study. Environ Health: a Glob Access Sci Source. 2013;12:23.

  46. 46.

    Jacobson MH, Barr DB, Marcus M, Muir AB, Lyles RH, Howards PP, et al. Serum polybrominated diphenyl ether concentrations and thyroid function in young children. Environ Res. 2016;149:222–30.

  47. 47.

    Mazdai A, Dodder NG, Abernathy MP, Hites RA, Bigsby RM. Polybrominated diphenyl ethers in maternal and fetal blood samples. Environ Health Perspect. 2003;111:1249–52.

  48. 48.

    Rose M, Bennett DH, Bergman A, Fangstrom B, Pessah IN, Hertz-Picciotto I. PBDEs in 2-5 year-old children from California and associations with diet and indoor environment. Environ Sci Technol. 2010;44:2648–53.

  49. 49.

    Stapleton HM, Eagle S, Anthopolos R, Wolkin A, Miranda ML. Associations between polybrominated diphenyl ether (PBDE) flame retardants, phenolic metabolites, and thyroid hormones during pregnancy. Environ Health Perspect. 2011;119:1454–9.

  50. 50.

    Stapleton HM, Eagle S, Sjodin A, Webster TF. Serum PBDEs in a North Carolina toddler cohort: associations with handwipes, house dust, and socioeconomic variables. Environ Health Perspect. 2012;120:1049–54.

  51. 51.

    Baskin D, Sommers I. Trajectories of exposure to community violence and mental health symptoms among serious adolescent offenders. Crim Justice Behav. 2015;42:587–609.

  52. 52.

    Azad MB, Lissitsyn Y, Miller GE, Becker AB, HayGlass KT, Kozyrskyj AL. Influence of socioeconomic status trajectories on innate immune responsiveness in children. PLoS ONE. 2012;7:e38669.

  53. 53.

    Ziyab AH, Karmaus W, Kurukulaaratchy RJ, Zhang H, Arshad SH. Developmental trajectories of Body Mass Index from infancy to 18 years of age: prenatal determinants and health consequences. J Epidemiol Community Health. 2014;68:934–41.

  54. 54.

    Chen Q, Just AC, Miller RL, Perzanowski MS, Goldstein IF, Perera FP, et al. Using latent class growth analysis to identify childhood wheeze phenotypes in an urban birth cohort. Ann Allergy Asthma Immunol. 2012;108:311–5. e311

  55. 55.

    Lupton SJ, McGarrigle BP, Olson JR, Wood TD, Aga DS. Human liver microsome-mediated metabolism of brominated diphenyl ethers 47, 99, and 153 and identification of their major metabolites. Chem Res Toxicol. 2009;22:1802–9.

  56. 56.

    Bramwell L, Glinianaia SV, Rankin J, Rose M, Fernandes A, Harrad S, et al. Associations between human exposure to polybrominated diphenyl ether flame retardants via diet and indoor dust, and internal dose: A systematic review. Environ Int. 2016;92-93:680–94.

  57. 57.

    Gyalpo T, Toms LM, Mueller JF, Harden FA, Scheringer M, Hungerbuhler K. Insights into PBDE uptake, body burden, and elimination gained from Australian Age-Concentration Trends Observed Shortly after Peak Exposure. Environ Health Perspect. 2015;123:978–84.

  58. 58.

    Quinn CL, Wania F. Understanding differences in the body burden-age relationships of bioaccumulating contaminants based on population cross sections versus individuals. Environ Health Perspect. 2012;120:554–9.

  59. 59.

    Darrow LA, Jacobson MH, Preston EV, Lee GE, Panuwet P, Hunter RE Jr, et al. Predictors of serum polybrominated diphenyl ether (PBDE) concentrations among children aged 1-5 Years. Environ Sci & Technol. 2017;51:645–54.

  60. 60.

    Costa O, Lopez-Espinosa MJ, Vizcaino E, Murcia M, Iniguez C, Navarrete-Munoz EM, et al. Dietary and household sources of prenatal exposure to polybrominated diphenyl ethers (PBDEs) in the INMA Birth Cohort (Spain). Environ Sci Technol. 2016;50:5935–44.

  61. 61.

    EPA. Reducing your child’s exposure to flame retardant chemicals. 2016, EPA-740-16-001.

  62. 62.

    S07621/A10050-A. NY State Senate Bill. New York, 2004.

  63. 63.

    Petreas M, Oros D. Polybrominated diphenyl ethers in California wastestreams. Chemosphere. 2009;74:996–1001.

  64. 64.

    Shaw SD, Blum A, Weber R, Kannan K, Rich D, Lucas D, et al. Halogenated flame retardants: do the fire safety benefits justify the risks? Rev Environ Health. 2010;25:261–305.

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This research was supported by NIH R01 ES021806. During preparation of this manuscript, WJC was supported by NIH T32 ES023772, NIH T32 ES007322, and EPA FP-91779001. We gratefully acknowledge the contribution of Miss Shenika Christopher who helped to identify potential determinants of interest for investigation in this study.

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Correspondence to Julie B. Herbstman.

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  • PBDE
  • Flame retardant
  • Exposure
  • Prenatal
  • Childhood

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