Fig. 6 | International Journal of Oral Science

Fig. 6

From: Macrophage-derived small extracellular vesicles promote biomimetic mineralized collagen-mediated endogenous bone regeneration

Fig. 6

Suppression of MSCs proliferative, immunomodulative and osteogenic potential after blocking EV secretion. a Schematic diagram. b Flow cytometry analysis of CD163+ and CD68+ cell numbers after blocking EV secretion. c Impaired MSC proliferation rate after blocking EV secretion. d Decreased mRNA levels of ALP, RUNX2, BMP2, and BGLAP in MSCs when treating cells with GW4869 conditioned medium. e Inhibition of BMP2 and Smad5 protein levels in MSCs when treating cells with GW4869 conditioned medium. *P < 0.05 vs DMSO

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