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Maternal obesity: focus on offspring cardiometabolic outcomes

International Journal of Obesity Supplements volume 10, pages 27–34 (2020)Cite this article

Abstract

Several human and animal studies have demonstrated that cardiometabolic parameters in infancy, childhood, adolescence and even adulthood are negatively influenced by many factors besides energy imbalance. Interestingly, maternal weight excess both before and during pregnancy seems to be a negative determinant of metabolic and cardiovascular outcomes in the offspring. This review includes both human and animal studies and finally highlights the link between maternal obesity and cardiometabolic disorders in offspring.

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Acknowledgements

Obesity Programs of nutrition, Education, Research and Assessment (OPERA) group members served as collaborators and approved the final version of the manuscript: Colao Annamaria, Savastano Silvia, Barrea Luigi, Muscogiuri Giovanna, Alviggi Carlo, Angrisani Luigi, Annunziata Giuseppe, Beguinot Francesco, Belfiore Annamaria, Belfiore Antonino, Bellastella Giuseppe, Biondi Bernadette, Bonaduce Domenico, Bordoni Laura, Brasacchio Caterina, Capaldo Brunella, Caprio Massimiliano, Cataldi Mauro, Cignarelli Angelo, Cittadini Antonello, Conforti Alessandro, Cuomo Rosario, De Placido Giuseppe, De Siena Marina, Di Carlo Costantino, Di Luigi Luigi, Di Nisio Andrea, Di Renzo Laura, Di Somma Carolina, Docimo Ludovico, Donini Lorenzo Maria, Federici Massimo, Foresta Carlo, Gabbianelli Rosita, Gambineri Alessandra, Gastaldelli Amalia, Giallauria Francesco, Giardiello Cristiano, Gnessi Lucio, Guida Brunella, Laudisio Daniela, Lenzi Andrea, Macchia Paolo Emidio, Manno Emilio, Marzullo Paolo, Migliaccio Silvia, Muratori Fabrizio, Musella Mario, Nardone Gerardo, Nicasto Vincenzo, Piazza Luigi, Pilone Vincenzo, Pivari Francesca, Pivonello Rosario, Pugliese Gabriella, Riccardi Gabriele, Ritieni Alberto, Salzano Ciro, Sanduzzi Alessandro, Sbraccia Paolo, Sesti Giorgio, Soldati Laura, Taglialatela Maurizio, Trimarco Bruno, Tuccinardi Dario.

Funding

The 2019 OPERA meeting was organized by Panta Rei Srl and sponsored by Novo Nordisk, Therascience, Bruno Pharma, Merck, Savio Pharma Italia Srl, IBSA Institut Biochimique SA, Bioitalia Srl, Cohesion Pharmaceutical, and Specchiasol Srl. Publication of this article as part of a supplement was sponsored by Panta Rei Srl, Naples, Italy. The meeting sponsors and organizer did not have access to the manuscripts and the authors maintained control of the content.

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Authors and Affiliations

  1. Endocrinology Unit, Department of Medical and Surgical Sciences, St Orsola-Malpighi Hospital, Alma Mater University of Bologna, Bologna, Italy

    Alessandra Gambineri

  2. Department of Neuroscience, Reproductive Science and Odontostomatology, University of Naples Federico II, Naples, Italy

    Alessandro Conforti

  3. Department of Medicine, Operative Unit of Andrology and Medicine of Human Reproduction, University of Padova, Padova, Italy

    Andrea Di Nisio

  4. Endocrinology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy

    Daniela Laudisio, Giovanna Muscogiuri, Luigi Barrea, Silvia Savastano & Annamaria Colao

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  1. Alessandra Gambineri
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on behalf of Obesity Programs of nutrition, Education, Research and Assessment (OPERA) Group

Contributions

The authors’ responsibilities were as follows: AG, AC, ADN and DL: were responsible for the concept of this paper and drafted the manuscript; GM, LB, SS and AC: provided a critical review of the paper. OPERA Group members participated to the revision of the manuscript. All authors and OPERA Group Members contributed to and agreed on the final version of the manuscript.

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Correspondence to Alessandra Gambineri.

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A Conforti received consulting fees from Merck Serono S.p.A. The remaining authors have nothing to disclose.

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Gambineri, A., Conforti, A., Di Nisio, A. et al. Maternal obesity: focus on offspring cardiometabolic outcomes. Int J Obes Supp 10, 27–34 (2020). https://doi.org/10.1038/s41367-020-0016-2

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