Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correspondence
  • Published:

Clinical Research

Fluctuation in body size and glymphatic system derangement in obesity

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout


  1. Livingston G, Huntley J, Sommerlad A, Ames D, Ballard C, Banerjee S, et al. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet. 2020;396:413–46.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Sun J, Zeng N, Hui J, Liu W, Zhao X, Chen S, et al. Association of variability in body size with neuroimaging metrics of brain health: a population-based cohort study. Lancet Reg Health West Pac. 2024;44:101015.

    PubMed  PubMed Central  Google Scholar 

  3. Inglese M, Bomsztyk E, Gonen O, Mannon LJ, Grossmann RI, Rusinek H. Dilated perivascular spaces: hallmarks of mild traumatic brain injury. Am J Neuroradiol. 2005;26:719–24.

    PubMed  PubMed Central  Google Scholar 

  4. Wardlaw JM, Smith C, Dichgans M. Small vessel disease: mechanisms and clinical implications. Lancet Neurol. 2019;18:684–96.

    Article  PubMed  Google Scholar 

  5. Bohr T, Hjorth PG, Holst SC, Hrabětová S, Kiviniemi V, Lilius T, et al. The glymphatic system: current understanding and modelling. iScience. 2022;29:104987.

    Article  Google Scholar 

  6. Gallina P, Nicoletti C, Scollato A, Lolli F. The “Glymphatic-Lymphatic System Pathology” and a new categorization of neurodegenerative disorders. Front Neurosci. 2021;15:669681.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Schwartz DL, Boespflug EL, Lahna DL, Pollock J, Roese NE, Silbert LC. Autoidentification of perivascular spaces in white matter using clinical field strength T1 and FLAIR MR imaging. Neuroimage. 2019;202:116126.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations



PG and FL contributed equally in conceptualization, drafting and reviewing the manuscript. Both the authors approved the final version of the article.

Corresponding author

Correspondence to Pasquale Gallina.

Ethics declarations

Competing interests

The authors declare no competing interests.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Gallina, P., Lolli, F. Fluctuation in body size and glymphatic system derangement in obesity. Int J Obes (2024).

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • DOI:


Quick links