Several studies show an increased risk of coronary heart disease (CHD) among people with obesity, but it is largely unknown whether this association also depends on a familial predisposition to obesity. This study examined if associations between Body Mass Index (BMI) or waist circumference (WC) and incident CHD differed among Danish female nurses with and without familial overweight and obesity. Analyses were based on data from the Danish Nurse Cohort (n = 20,701). Self-reported height, weight and self-measured WC were assessed in 1999, as was information on familial overweight/obesity, defined as having one or both parents with overweight/obesity. Information on the development of or death from CHD was collected from nationwide Danish registries in 2015. Analyses were based on Cox proportional hazard regression models adjusted for potential confounding factors. Both BMI and WC were directly associated with CHD risk, but we found no evidence of effect modification from familial predisposition to obesity. Hence a familial predisposition to obesity does not seem to influence the risk of CHD associated with general or central obesity.
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WHO. Obesity and overweight [Internet]. World Health Organization. 2020 [cited 2020 Mar 9]: https://www.who.int/en/news-room/fact-sheets/detail/obesity-and-overweight.
WHO Cardiovascular Diseases [Internet]. [cited 2020 Oct]. Available from: https://www.who.int/health-topics/cardiovascular-diseases/.
Manson JE, Colditz GA, Stampfer MJ, Willett WC, Rosner B, Monson RR, et al. A prospective study of obesity and risk of coronary heart disease in women. N Engl J Med. 1990;322:882–9.
Flint AJ, Rexrode KM, Hu FB, Glynn RJ, Caspard H, Manson JE, et al. Body mass index, waist circumference, and risk of coronary heart disease: a prospective study among men and women. Obes Res Clin Pract. 2010;4:171–81.
Rexrode KM, Carey VJ, Hennekens CH, Walters EE, Colditz GA, Stampfer MJ, et al. Abdominal adiposity and coronary heart disease in women. JAMA. 1998;280:1843–8.
Yusuf S, Hawken S, Ôunpuu S, Bautista L, Franzosi MG, Commerford P, et al. Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case-control study. The Lancet. 2005;366:1640–9.
Cooper R, Pinto Pereira SM, Power C, Hyppönen E. Parental obesity and risk factors for cardiovascular disease among their offspring in mid-life: findings from the 1958 British Birth Cohort Study. Int J Obes. 2013;37:1590–6.
Han TS, Hart CL, Haig C, Logue J, Upton MN, Watt GCM, et al. Contributions of maternal and paternal adiposity and smoking to adult offspring adiposity and cardiovascular risk: the Midspan Family Study. BMJ Open. 2015;5:1–12.
Hippe M, Vestbo J, Hein HO, Borch-Johnsen K, Jensen G, Sørensen TI. Familial predisposition and susceptibility to the effect of other risk factors for myocardial infarction. J Epidemiol Community Health. 1999;53:269–76.
Gottesman O, Drill E, Lotay V, Bottinger E, Peter I. Can genetic pleiotropy replicate common clinical constellations of cardiovascular disease and risk?. PLOS ONE. 2012;7:e46419.
Rankinen T, Sarzynski MA, Ghosh S, Bouchard C. Are there genetic paths common to obesity, cardiovascular disease outcomes, and cardiovascular risk factors?. Circ Res. 2015;116:909–22.
Hundrup YA, Simonsen MK, Jørgensen T, Obel EB. Cohort profile: The Danish nurse cohort. Int J Epidemiol. 2011;41:1241–7.
Keshtkar AA, Semnani S, Pourshams A, Khademi H, Roshandel G, Boffetta P, et al. Pictogram use was validated for estimating individual’s body mass index. J Clin Epidemiol. 2009;63:655–9.
Bulik C, Wade T, Heath A, Martin N, Stunkard A, Eaves L. Relating body mass index to figural stimuli: population-based normative data for Caucasians. Int J Obes. 2001;25:1517–24.
Grant JF, Chittleborough CR, Taylor AW. Parental midlife body shape and association with multiple adult offspring obesity measures: North West Adelaide Health Study. Allison DB, editor. PLOS ONE. 2015;10:1–15.
Bigaard J, Spanggaard I, Thomsen BL, Overvad K, Tjønneland A. Self-reported and technician-measured waist circumferences differ in middle-aged men and women. J Nutr. 2005;135:2263–70.
Merrill RM, Richardson JS. Validity of self-reported height, weight, and body mass index: findings from the National Health and Nutrition Examination Survey, 2001–2006. Prev Chronic Dis. 2009;6:1–10.
Nyholm M, Gullberg B, Merlo J, Lundqvist-Persson C, Råstam L, Lindblad U. The validity of obesity based on self-reported weight and height: implications for population studies. Obesity. 2007;15:197–208.
Skeie G, Borch K, Mode N, Henningsen M. Validity of self-reported body mass index among middle-aged participants in the Norwegian Women and Cancer study. Clin Epidemiol. 2015;2015:313–23.
Seaborg E. The dangers of visceral fat [Internet]. Endocrine News. 2013 [cited 2020 May 17]. https://endocrinenews.endocrine.org/the-dangers-of-visceral-fat/.
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Hammer, M.D., Andersen, A.J., Larsen, S.C. et al. The association between general and central obesity and the risks of coronary heart disease in women with and without a familial predisposition to obesity: findings from the Danish Nurse Cohort. Int J Obes (2021). https://doi.org/10.1038/s41366-021-00990-4