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Clinical Research

Impact of body mass index (BMI) on the success rate of fresh embryo transfer in women undergoing first in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatment

International Journal of Obesity volume 46, pages 202–210 (2022)Cite this article

Subjects

Abstract

Objective

To investigate the impact of body mass index (BMI) on the success rate and prenatal outcomes of fresh embryo transfer in women undergoing their first in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatment.

Methods

It is a post-hoc analysis of a prospective observational cohort study. 2569 Chinese women were grouped in quintiles of BMI and according to the official Chinese classification of body weight. IVF/ICSI and pregnancy outcomes were compared between groups.

Results

BMI was not associated with IVF/ICSI pregnancy outcomes including hCG positive rate, clinical pregnancy rate, implantation rate, ectopic pregnancy rate, ongoing pregnancy rate, early miscarriage rate, and live birth rate. However, it was negatively related to some pregnancy complications such as gestational diabetes mellitus (GDM) and hypertension. Additionally, the proportion of Cesarean-section was increased with BMI. As for prenatal outcomes, the current results showed no statistical difference in the number of male and female newborn, the proportion of low live birth weight (<2500 g), macrosomia (≥4000 g) (both in all live birth and full-term live birth), and premature delivery (<37 weeks).

Conclusions

The current study showed that BMI was not associated with embryo transfer outcomes after fresh embryo transfer in women undergoing their first IVF/ICSI treatment, whereas BMI was associated with GDM and gestational hypertension.

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Acknowledgements

We thank our patients for their participation, and we thank the Reproductive and Genetic Hospital of CITIC-Xiangya for supporting the study. The study was supported by the Hunan province college students research learning and innovative project grant (S201910542038).

Author information

Author notes

  1. These authors contributed equally: Fei Gong, Berthold Hocher.

Authors and Affiliations

  1. Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha, China

    Huijun Chen, Sufen Cai, Ge Lin, Fei Gong & Berthold Hocher

  2. Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, School of Medicine, Hunan Normal University, Changsha, China

    Jian Li, Suimin Zeng, Chenjun Yin, Weihong Kuang, Kexin Cheng, Yao Jiang, Mingqiu Tao & Berthold Hocher

  3. Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha, China

    Sufen Cai, Ge Lin & Fei Gong

  4. Department of Nephrology, Charité-Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany

    Chang Chu

  5. Fifth Department of Medicine (Nephrology/Endocrinology/Rheumatology), University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany

    Chang Chu, Johann-Georg Hocher & Berthold Hocher

  6. Key Laboratory of Stem Cells and Reproductive Engineering, Ministry of Health, Changsha, China

    Ge Lin & Fei Gong

  7. Institute of Medical Diagnostics, IMD, Berlin, Germany

    Berthold Hocher

Authors
  1. Huijun Chen
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  2. Jian Li
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  10. Chang Chu
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  12. Ge Lin
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Contributions

Conceptualization: BH. Data curation: HC, JL, SC, SZ, CY, WK, KC, YJ, MT, YJ, MT, CC. Formal analysis: HC and BH. Methodology: HC and BH. Project administration: SC. Software: HC. Supervision: GL, FG and BH. Validation: HC and BH. Writing-original draft: HC. and BH. Writing– review & editing: HC, JH, GL, FG, BH.

Corresponding authors

Correspondence to Fei Gong or Berthold Hocher.

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Chen, H., Li, J., Cai, S. et al. Impact of body mass index (BMI) on the success rate of fresh embryo transfer in women undergoing first in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatment. Int J Obes 46, 202–210 (2022). https://doi.org/10.1038/s41366-021-00978-0

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