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Epidemiology and Population Health

Effects of abdominal obesity on the association between air pollution and kidney function

Abstract

Objectives

This study aimed to evaluate the associations between ambient air pollutants, obesity, and kidney function.

Subjects/methods

We enrolled 3345 people who had undergone health checkups at Seoul National University Hospital. We recorded the annual average concentrations of ambient air pollutants, including particulate matter with an aerodynamic diameter of ≤10 μm (PM10), nitrogen dioxide (NO2), sulfur dioxide (SO2), and carbon monoxide (CO), in each subject’s residential area. Various obesity traits, such as body mass index, waist circumference, and visceral and subcutaneous adipose tissue areas, were measured by quantified computerized tomography (CT), and kidney function was assessed in relation to estimated glomerular filtration rate as an indicator of kidney function.

Results

High PM10, NO2, SO2, and CO concentrations were significantly associated with decreased kidney function (β = −2.39 and standard error = 0.32, −1.00 and 0.31, −1.23 and 0.28, and −1.32 and 0.29, respectively), and with the prevalence of chronic kidney disease (CKD). The association between air pollutant concentrations and decreased kidney function, including CKD, was stronger among those with high abdominal adiposity, as defined by CT measurement. For example, the association between increased concentrations of air pollutants and the prevalence of CKD was stronger in the group with greater visceral adiposity than in the group with less visceral adiposity (aORs = 1.29 vs 1.16 for PM10, 1.42 vs 1.21 for SO2, and 1.27 vs 1.11 for CO).

Conclusions

Long-term exposure to higher concentrations of air pollutants was unfavorably associated with kidney function and CKD prevalence, especially in people with abdominal obesity. This may indicate a high susceptibility to air pollutants in obese people.

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Acknowledgements

This research was supported by the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (grant number 2018R1D1A1A09083190).

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Correspondence to Jin-Ho Park or Hyun-Jin Kim.

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The authors who have taken part in this study declare that they do not have anything to disclose regarding funding or conflict of interest with respect to this paper.

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Jeong, SM., Park, JH., Kim, HJ. et al. Effects of abdominal obesity on the association between air pollution and kidney function. Int J Obes 44, 1568–1576 (2020). https://doi.org/10.1038/s41366-020-0540-8

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