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Bariatric Surgery

Baseline TSH levels and short-term weight loss after different procedures of bariatric surgery

International Journal of Obesity volume 45, pages 326–330 (2021)Cite this article

Subjects

Abstract

Background

Bariatric surgery is a valuable therapeutic option in the treatment of obesity but the outcomes show a large subject-to-subject variability yet to be explained. Thyroid function may represent an involved factor and we have only few controversial data about its influence.

Subjects/methods

We retrospectively assessed using a longitudinal approach the relation between baseline TSH levels and short-term (6 and 12 months) weight loss in 387 euthyroid patients who underwent laparoscopic gastric banding (LAGB; n = 187) or sleeve gastrectomy (SG; n = 200).

Results

After LAGB, patients with low-normal TSH levels (0.40–1.40 mUI/L) had higher percent total weight loss, ∆BMI and percent excess weight loss when compared to patients with normal (1.41–2.48 mUI/L) and high-normal (2.49–4.00 mUI/L) TSH (p < 0.05). Conversely, no association was detected after SG (p = 0.17). The multivariable regression analysis showed that also baseline BMI (6–12 months) and HOMA2-IR (only at 6 months) were independently associated with the outcomes.

Conclusions

TSH levels may influence the short-term weight loss response after LAGB. The lack of association after SG suggests that the influence of baseline endocrine and metabolic factors may not be relevant for procedures with greater and more immediate calorie intake restriction.

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References

  1. Swinburn BA, Sacks G, Hall KD, McPherson K, Finegood DT, Moodie ML, et al. The global obesity pandemic: shaped by global drivers and local environments. Lancet. 2011;378:804–14.

    Article  Google Scholar 

  2. Peeters A, Barendregt JJ, Willekens F, Mackenbach JP, Mamun AA, Bonneux L, et al. Obesity in adulthood and its consequences for life expectancy: a life-table analysis. Ann Intern Med. 2003;138:24–32.

    Article  Google Scholar 

  3. Jakobsen GS, Småstuen MC, Sandbu R, Nordstrand N, Hofsø D, Lindberg M, et al. Association of bariatric surgery vs medical obesity treatment with long-term medical complications and obesity-related comorbidities. JAMA. 2018;319:291–301.

    Article  Google Scholar 

  4. Eldar S, Heneghan H, Brethauer S, Schauer P. Bariatric surgery for treatment of obesity. Int J Obes. 2011;35:S16–S21.

    Article  Google Scholar 

  5. Fox CS, Pencina MJ, D’Agostino RB, Murabito JM, Seely EW, Pearce EN, et al. Relations of thyroid function to body weight: cross-sectional and longitudinal observations in a community-based sample. Arch Int Med. 2008;168:587–92.

    Article  Google Scholar 

  6. Mullur R, Liu Y-Y, Brent GA. Thyroid hormone regulation of metabolism. Physiol Rev. 2014;94:355–82.

    Article  CAS  Google Scholar 

  7. Liu G, Liang L, Bray GA, Qi L, Hu FB, Rood J, et al. Thyroid hormones and changes in body weight and metabolic parameters in response to weight loss diets: the POUNDS LOST trial. Int J Obes. 2017;41:878–86.

    Article  CAS  Google Scholar 

  8. Marzullo P, Minocci A, Mele C, Fessehatsion R, Tagliaferri M, Pagano L, et al. The relationship between resting energy expenditure and thyroid hormones in response to short-term weight loss in severe obesity. PLoS ONE. 2018;13:e0205293.

    Article  Google Scholar 

  9. Hashimoto K, Tagami T, Yamakage H, Muranaka K, Tanaka M, Odori S, et al. Serum free thyroxine levels is associated with the efficacy of weight reduction therapy in obese female patients. Endocr J. 2016;63:221–9.

    Article  CAS  Google Scholar 

  10. Wolters B, Lass N, Reinehr T. TSH and free triiodothyronine concentrations are associated with weight loss in a lifestyle intervention and weight regain afterwards in obese children. Eur J Endocrinol. 2013;168:323–9.

    Article  CAS  Google Scholar 

  11. Brethauer SA, Kim J, El Chaar M, Papasavas P, Eisenberg D, Rogers A, et al. Standardized outcomes reporting in metabolic and bariatric surgery. Obes Surg. 2015;25:587–606.

    Article  Google Scholar 

  12. Janssen IM, Homan J, Schijns W, Betzel B, Aarts EO, Berends FJ, et al. Subclinical hypothyroidism and its relation to obesity in patients before and after Roux-en-Y gastric bypass. Surg Obes Relat Dis. 2015;11:1257–63.

    Article  Google Scholar 

  13. De Moraes CMM, Mancini MC, de Melo ME, Figueiredo DA, Villares SMF, Rascovski A, et al. Prevalence of subclinical hypothyroidism in a morbidly obese population and improvement after weight loss induced by Roux-en-Y gastric bypass. Obes Surg. 2005;15:1287–91.

    Article  Google Scholar 

  14. Neves JS, Souteiro P, Oliveira SC, Pedro J, Magalhães D, Guerreiro V, et al. Preoperative thyroid function and weight loss after bariatric surgery. Int J Obes. 2019;43:432–6.

    Article  CAS  Google Scholar 

  15. Muraca E, Ciardullo S, Oltolini A, Zerbini F, Bianconi E, Perra S, et al. Resting energy expenditure in obese women with primary hypothyroidism and appropriate levothyroxine replacement therapy. J Clin Endocrinol Metab. 2020;105:dgaa097.

    Article  Google Scholar 

  16. Sesti G, Folli F, Perego L, Hribal ML, Pontiroli AE. Effects of weight loss in metabolically healthy obese subjects after laparoscopic adjustable gastric banding and hypocaloric diet. PLoS ONE. 2011;6:e17737.

    Article  Google Scholar 

  17. Bradley D, Magkos F, Klein S. Effects of bariatric surgery on glucose homeostasis and type 2 diabetes. Gastroenterology. 2012;143:897–912.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Medicine and Rehabilitation, Policlinico di Monza, Monza, Italy

    Emanuele Muraca, Alice Oltolini, Giuseppina Manzoni, Silvia Perra, Francesca Zerbini, Eleonora Bianconi, Rosa Cannistraci, Stefano Ciardullo, Guido Lattuada & Gianluca Perseghin

  2. Centro per lo Studio, la Ricerca e la terapia dell’Obesità, Policlinico di Monza, Monza, Italy

    Mattia Pizzi & Pietro Pizzi

  3. Clinical Psychology, Policlinico di Monza, Monza, Italy

    Matteo Villa

  4. Department of Medicine and Surgery, Università degli Studi Milano Bicocca, Monza, Italy

    Rosa Cannistraci, Stefano Ciardullo & Gianluca Perseghin

Authors
  1. Emanuele Muraca
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  2. Alice Oltolini
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  3. Mattia Pizzi
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  4. Matteo Villa
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  5. Giuseppina Manzoni
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  6. Silvia Perra
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  7. Francesca Zerbini
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  8. Eleonora Bianconi
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  9. Rosa Cannistraci
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  10. Stefano Ciardullo
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  11. Pietro Pizzi
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  12. Guido Lattuada
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  13. Gianluca Perseghin
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Corresponding author

Correspondence to Gianluca Perseghin.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethics

The protocol (TIREOBARIATRIC) was approved by the ethics committee della Provincia di Monza e Brianza.

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Informed consent has been obtained from each patient or subject after full explanation of the purpose and nature of all procedures used.

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Muraca, E., Oltolini, A., Pizzi, M. et al. Baseline TSH levels and short-term weight loss after different procedures of bariatric surgery. Int J Obes 45, 326–330 (2021). https://doi.org/10.1038/s41366-020-00665-6

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  • DOI: https://doi.org/10.1038/s41366-020-00665-6

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