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Epidemiology and Population Health

Is the positive relationship of infant weight gain with adolescent adiposity attenuated by moderate-to-vigorous physical activity in childhood? Evidence from the Millennium Cohort Study

International Journal of Obesity volume 45, pages 84–94 (2021)Cite this article

Subjects

Abstract

Objective

Rapid infant weight gain is a key risk factor for paediatric obesity, yet there is very little evidence on how healthy behaviours in childhood might modify this association. We aimed to examine how the association of infant weight gain with adolescent adiposity might be attenuated by moderate-to-vigorous physical activity (MVPA) in childhood.

Methods

The sample comprised 4666 children in the UK Millennium Cohort Study. The two outcomes were BMI Z-score and % fat at 14 years. Sex-stratified regression models were developed testing for interactions between infant weight Z-score gain between 0 and 3 years (continuous or categorical) and MVPA at 7 years (continuous or binary). Models were sequentially adjusted for basic covariates, socioeconomic variables, and parental BMI levels.

Results

Effect modification was observed in boys but not girls and, among boys, was stronger for % fat than BMI. In a fully adjusted model for boys, the association between infant weight Z-score gain and adolescent % fat was 1.883 (1.444, 2.322) if MVPA < 60 min/day and 1.305 (0.920, 1.689) if MVPA ≥ 60 min/day; the difference between these two estimates being −0.578 (−1.070, −0.087). Similarly, % fat was 2.981 (1.596, 4.367) units higher among boys who demonstrated rapid infant weight gain (+0.67 to +1.34 Z-score) compared to normal weight gain (−0.67 to +0.67 Z-scores), but having MVPA ≥ 60 min/day reduced this effect size by −2.259 (−3.989, −0.535) units.

Conclusions

In boys, ~75% of the excess % fat at 14 years associated with rapid infant weight gain was attenuated by meeting the MVPA guideline. In boys known to have demonstrated rapid infant weight gain, increasing childhood MVPA levels, with the target of ≥60 min/day, might therefore go a long way to towards offsetting their increased risk for adolescent obesity. The lack of effect modification in girls is likely due to lower MVPA levels.

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Fig. 1: The association of infant weight gain categories (0–3 years) with % fat (14 years) in boys, according to whether or not MVPA guidelines (7 years) were met.

Code availability

Available from the first author upon request.

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Funding

This work was funded by the UK Medical Research Council (WJ New Investigator Research Grant: MR/P023347/1). WJ acknowledges support from the National Institute for Health Research (NIHR) Leicester Biomedical Research Centre, which is a partnership between University Hospitals of Leicester NHS Trust, Loughborough University, and the University of Leicester.

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Affiliations

  1. School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK

    William Johnson, Tom Norris, Rebekah De Freitas, Natalie Pearson & Silvia Costa

  2. Division of Surgery and Interventional Sciences, Faculty Medical Sciences, University College London, London, UK

    Mark Hamer

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WJ conceptualized the study, carried out the analyses, and drafted the initial manuscript. All authors made substantial contributions to the interpretation of the data, revised the manuscript critically for important intellectual content, gave final approval of the version to be published, and agree to be accountable for all aspects of the work.

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Correspondence to William Johnson.

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Johnson, W., Norris, T., De Freitas, R. et al. Is the positive relationship of infant weight gain with adolescent adiposity attenuated by moderate-to-vigorous physical activity in childhood? Evidence from the Millennium Cohort Study. Int J Obes 45, 84–94 (2021). https://doi.org/10.1038/s41366-020-00656-7

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